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T-3775440

inhibits lysine specific demethylase 1 (LSD1); structure in first source

Also Known As:

N-(4-(2-((cyclopropylmethyl)amino)cyclopropyl)phenyl)-1-methyl-1H-pyrazole-4-carboxamide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Dairiki, R: 1 article (09/2017)
2.	Gamo, K: 1 article (09/2017)
3.	Hayashi, A: 1 article (09/2017)
4.	Ishikawa, Y: 1 article (09/2017)
5.	Matsumoto, S: 1 article (09/2017)
6.	Miyashita, H: 1 article (09/2017)
7.	Mizutani, A: 1 article (09/2017)
8.	Morimoto, M: 1 article (09/2017)
9.	Nakamura, K: 1 article (09/2017)
10.	Nakayama, A: 1 article (09/2017)

Related Diseases

1.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/2017 - "Here, we describe the anticancer effects and mechanism of action of T-3775440 in small-cell lung cancer (SCLC). "
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/11/2017 - "We previously identified an irreversible LSD1 inhibitor T-3775440, which exerts antileukemic activities in a subset of acute myeloid leukemia (AML) cell lines by inducing cell transdifferentiation. "
3.	Neoplasms (Cancer) 01/01/2017 - "T-3775440 inhibited proliferation of SCLC cells in vitro and retarded SCLC tumor growth in vivo T-3775440 disrupted the interaction between LSD1 and the transcriptional repressor INSM1, thereby inhibiting expression of neuroendocrine-associated genes, such as ASCL1 INSM1 silencing phenocopied the effects of T-3775440 on gene expression and cell proliferation, consistent with the likelihood T-3775440 mediated its effects in SCLC by inhibiting INSM1. "
4.	Leukemia 01/01/2017 - "T-3775440 is an irreversible inhibitor of the chromatin demethylase LSD1, which exerts antiproliferative effects by disrupting the interaction between LSD1 and GFI1B, a SNAG domain transcription factor, inducing leukemia cell transdifferentiation. "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Chromatin