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trastuzumab-vc-MMAE

antibody–drug conjugate; MMAE - monomethyl auristatin E

Also Known As:

T-vc-MMAE; trastuzumab-valine-citrulline-monomethyl auristatin E

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        Humanized Monoclonal Antibodies: 217
        Trastuzumab: 9058
        trastuzumab-vc-MMAE: 6
        Immunoconjugates: 3432
        trastuzumab-vc-MMAE: 6
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        Humanized Monoclonal Antibodies: 217
        Trastuzumab: 9058
        trastuzumab-vc-MMAE: 6
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        Humanized Monoclonal Antibodies: 217
        Trastuzumab: 9058
        trastuzumab-vc-MMAE: 6
        Immunoconjugates: 3432
        trastuzumab-vc-MMAE: 6
- Peptides: 82426
  - Oligopeptides: 519
    - trastuzumab-vc-MMAE: 6
Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Physiological Effects of Drugs: 1
    - Immunologic Factors: 7984
      - Immunoconjugates: 3432
        trastuzumab-vc-MMAE: 6

Experts

1.	Shah, Dhaval K: 4 articles (01/2021 - 02/2019)
2.	Guo, Leiming: 3 articles (01/2020 - 02/2019)
3.	Singh, Aman P: 3 articles (01/2020 - 02/2019)
4.	Verma, Ashwni: 3 articles (01/2020 - 02/2019)
5.	Wong, Gloria Gao-Li: 3 articles (01/2020 - 02/2019)
6.	Bussing, David: 1 article (01/2021)
7.	Li, Zhe: 1 article (01/2021)
8.	Meyer, Lyndsey F: 1 article (01/2021)
9.	Sharma, Sharad: 1 article (01/2021)
10.	Cheng, Hsuan-Ping: 1 article (01/2020)

Related Diseases

1.

Neoplasms (Cancer)

01/01/2020 - "In addition, tumor growth inhibition (TGI) studies were conducted in all three xenografts at different T-vc-MMAE dose levels. "
04/03/2023 - "Trastuzumab-vc-MMAE was used as the model ADC, and NCI-N87 tumor-bearing xenografts were used as the animal model. "
01/01/2020 - "Plasma and tumor PK of T-vc-MMAE was analyzed in N87, GFP-MCF7, and coculture tumor-bearing mice. "
01/01/2023 - "ABC3315 increased the IC50 of MMAE against human cancer cell lines by > 500-fold with no impact on the cytotoxicity of MMAE ADCs, including polatuzumab vedotin (PV) and trastuzumab-vc-MMAE (TvcMMAE). "
01/01/2020 - "Two different Trastuzumab-based ADCs, T-DM1 (no bystander effect) and T-vc-MMAE (with a bystander effect), were evaluated in high-HER2 (N87) and low-HER2 (MDA-MB-453) expressing tumors, with or without the coadministration of 1, 3, or 8-fold higher Trastuzumab. "

Related Drugs and Biologics

1.	trastuzumab-vc-MMAE
2.	Trastuzumab (Herceptin)
3.	Growth Factor Receptors
4.	polatuzumab vedotin