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N,7- dimethyl- 3- (phenylsulfonyl)- 6,7,8,9- tetrahydropyrazolo(1,5- a)pyrido(3,4- e)pyrimidin- 2- amine

a 5-HT6 receptor antagonist; structure in first source

Also Known As:

AVN-322

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - N,7-dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo(1,5-a)pyrido(3,4-e)pyrimidin-2-amine: 2

Experts

1.	Demise, Desalegn Getnet: 1 article (01/2020)
2.	Gufue, Zenawi Hagos: 1 article (01/2020)
3.	Hailu, Nigus Alemu: 1 article (01/2020)
4.	Tsegay, Etsay Weldekidan: 1 article (01/2020)
5.	Ivachtchenko, Alexandre V: 1 article (01/2017)
6.	Ivanenkov, Yan A: 1 article (01/2017)
7.	Okun, I M: 1 article (01/2017)
8.	Veselov, Mark S: 1 article (01/2017)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2017 - "Taking into account its good safety profile and favorable pharmacokinetics, AVN-322 can be reasonably considered as a novel drug candidate for the treatment of neurological disorders such as AD and/or schizophrenia." 01/01/2017 - "We describe results of preclinical development of a novel and highly selective and potent 5- HT6R antagonist, AVN-322, as a clinical candidate for the treatment of AD to improve concurrent debilitation of memory and cognition in the AD patients, and schizophrenia as a substance with antipsychotic effect. " 01/01/2020 - "SGS-518, ABT-354, Lu AE58054, SB-742,457, S-518, AVN-211, AVN-322, SYN-114 and SYN-120 are serotonin 6 receptor antagonists and aripiprazole-controlled release serotonin 7 receptor agonists under clinical trial for schizophrenia. "
2.	Cognitive Dysfunction 01/01/2017 - "AVN-322 significantly restored both scopolamine- and MK-801-induced cognitive dysfunction and demonstrated antipsychotic potential. "
3.	Nervous System Diseases (Neurological Disorders) 01/01/2017 - "Taking into account its good safety profile and favorable pharmacokinetics, AVN-322 can be reasonably considered as a novel drug candidate for the treatment of neurological disorders such as AD and/or schizophrenia."

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Scopolamine (Hyoscine)
3.	Aripiprazole (Abilify)
4.	(2- (6- fluoro- 1H- indol- 3- yl)- ethyl)- (3- (2,2,3,3- tetrafluoropropoxy)benzyl)amine
5.	serotonin 7 receptor
6.	serotonin 6 receptor
7.	3-sulfonyl-pyrazolo(1,5-a)pyrimidine