STK899704

01/01/2018 - "Overall, our results suggest that STK899704 is a promising anticancer chemotherapeutic that may replace existing therapies, particularly for skin cancer."
01/01/2018 - "Furthermore, the efficacy of STK899704 was nearly 2 times higher than that of 5-fluorouracil, a widely used skin cancer therapeutic. "

01/01/2018 - "In this study, our investigation is further extended into animal model to evaluate the effect of STK899704 on skin carcinogenesis in vivo. "
01/01/2017 - "Our in vivo carcinogenesis model further showed that STK 899704 is potent in both the prevention and regression of tumors, remarkably reducing the number and volume of skin tumor by STK899704 treatment. "
01/01/2018 - "A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model."

11/01/2018 - "STK899704, a novel synthetic agent, has been reported to exhibit anticancer effects towards numerous cancer cells. "
01/01/2018 - "The novel synthetic compound designated STK899704 (PubChem CID: 5455708) suppresses the proliferation of a broad range of cancer cell types. "
01/01/2018 - "Surprisingly, almost 80% of the tumors treated with STK899704 were regressed with a one-fifth reduction in tumor volume. "
01/01/2018 - "STK899704 inhibited microtubule polymerization leading to mitotic arrest and suppressed the proliferation of various cancer cell lines as well as multidrug resistance cancer cell lines. "
01/01/2017 - "STK899704 suppressed the proliferation of cancer cell lines from various origins with IC50 values ranging from 0.2 to 1.0 μM. "

01/01/2018 - "These findings suggest that the novel anti-proliferative small molecule STK899704 promotes cell death by inducing DNA damage response pathways and senescence after cell cycle arrest, being a potential drug for treating human lung cancers."

11/01/2018 - "These results suggest that STK899704 can be used to treat human colon cancer. "
11/01/2018 - "Additionally, STK899704 inhibited stemness gene expression and sphere formation in colon cancer stem cells. "
11/01/2018 - "In the wound healing assay, STK899704 significantly inhibited the motility of colon cancer cells. "
11/01/2018 - "However, the effect of STK899704 on the biological properties of colon cancer, including cancer cell migration and cancer stem cells (CSCs), remains unknown. "