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5TR1 aptamer

a MUC1 aptamer used in tumor-targeted drug delivery

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Oligonucleotides: 5145
      - Nucleotide Aptamers: 598
        5TR1 aptamer: 6

Experts

1.	Abnous, Khalil: 5 articles (09/2020 - 04/2016)
2.	Ramezani, Mohammad: 4 articles (09/2020 - 04/2016)
3.	Alibolandi, Mona: 2 articles (09/2020 - 01/2017)
4.	Taghdisi, Seyed Mohammad: 2 articles (01/2018 - 01/2017)
5.	Taghavi, Sahar: 2 articles (01/2017 - 04/2016)
6.	Eisvand, Farhad: 1 article (09/2020)
7.	Hadizadeh, Farzin: 1 article (09/2020)
8.	Mohammad Taghdisi, Seyed: 1 article (09/2020)
9.	Nejabat, Mojgan: 1 article (09/2020)
10.	Soltani, Fatemeh: 1 article (09/2020)

Related Diseases

1.	Neoplasms (Cancer) 09/25/2020 - "Moreover, 5TR1 aptamer-modified NPs could effectively deliver DOXor SmacN6 to C26 cancer cells (MUC1 positive) in comparison with the non-targeted one (p < 0.001). " 12/01/2018 - "5TR1 aptamer-PEGylated liposomal doxorubicin enhances cellular uptake and suppresses tumour growth by targeting MUC1 on the surface of cancer cells." 01/01/2017 - "Chitosan-modified PLGA nanoparticles tagged with 5TR1 aptamer for in vivo tumor-targeted drug delivery." 12/01/2018 - "The results suggested that 5TR1 aptamer is promising ligand for active targeting which improves therapeutic efficiency of PLD in cancer therapy." 01/01/2018 - "In this study, epirubicin (EPI)-loaded-NAS-24-functionalized PEI-PEG-5TR1 aptamer coated selenium nanoparticles (SeNPs), known as the ENPPASe complex, were developed and used for targeted delivery of both EPI (anticancer drug) and NAS-24 aptamer (apoptosis induction agent) to MCF7 (human breast carcinoma cell) and C26 (murine colon carcinoma cell) cancer cells using 5TR1 aptamer as the target agent. "
2.	Breast Neoplasms (Breast Cancer) 04/01/2016 - "Preparation and evaluation of polyethylenimine-functionalized carbon nanotubes tagged with 5TR1 aptamer for targeted delivery of Bcl-xL shRNA into breast cancer cells." 01/01/2018 - "In this study, epirubicin (EPI)-loaded-NAS-24-functionalized PEI-PEG-5TR1 aptamer coated selenium nanoparticles (SeNPs), known as the ENPPASe complex, were developed and used for targeted delivery of both EPI (anticancer drug) and NAS-24 aptamer (apoptosis induction agent) to MCF7 (human breast carcinoma cell) and C26 (murine colon carcinoma cell) cancer cells using 5TR1 aptamer as the target agent. "
3.	Carcinoma (Carcinomatosis) 01/01/2018 - "In this study, epirubicin (EPI)-loaded-NAS-24-functionalized PEI-PEG-5TR1 aptamer coated selenium nanoparticles (SeNPs), known as the ENPPASe complex, were developed and used for targeted delivery of both EPI (anticancer drug) and NAS-24 aptamer (apoptosis induction agent) to MCF7 (human breast carcinoma cell) and C26 (murine colon carcinoma cell) cancer cells using 5TR1 aptamer as the target agent. "

Related Drugs and Biologics

1.	Epirubicin (Ellence)
2.	Selenium
3.	Chitosan
4.	Carbon Nanotubes (Carbon Nanotube)
5.	Small Interfering RNA (siRNA)
6.	Mucin-1 (CA 15-3 Antigen)
7.	Polyethyleneimine
8.	Ligands
9.	Copper
10.	liposomal doxorubicin (Doxil)

Related Therapies and Procedures

1.	Therapeutics