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isourolithin A

has antineoplastic activity; structure in first source

Also Known As:

3,9-dihydroxy-6H-dibenzo(b,d)pyran-6-one; 3,9-dihydroxydibenzopyran-6-one; IsoUro-A

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        isourolithin A: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        isourolithin A: 3

Experts

1.	González-Sarrías, Antonio: 3 articles (08/2018 - 04/2016)
2.	Espín, Juan Carlos: 2 articles (08/2018 - 03/2017)
3.	García-Villalba, Rocío: 2 articles (03/2017 - 04/2016)
4.	Tomás-Barberán, Francisco A: 2 articles (03/2017 - 04/2016)
5.	Ávila-Gálvez, María Ángeles: 1 article (08/2018)
6.	Núñez-Sánchez, María Ángeles: 1 article (03/2017)
7.	Espín, Juan C: 1 article (04/2016)
8.	Romo-Vaquero, María: 1 article (04/2016)
9.	Selma, María V: 1 article (04/2016)

Related Diseases

1.	Weight Gain 04/01/2016 - "This suggests that weight gain favours the growth of bacteria capable of producing urolithin B and/or isourolithin A with respect to urolithin A-producing bacteria. "
2.	Neoplasms (Cancer) 03/01/2017 - "IsoUro-A exerts strong antiproliferative activity, which is reduced by the extensive glucuronidation at 9-position in cancer cells. "
3.	Colonic Neoplasms (Colon Cancer) 03/01/2017 - "Herein, we describe for the first time the antiproliferative effect of IsoUro-A, compared to Uro-A, against both human colon cancer (Caco-2) and normal (CCD18-Co) cell lines. "
4.	Breast Neoplasms (Breast Cancer) 08/15/2018 - "Since phase-II metabolites can reach systemic tissues such as malignant breast tumors, we aimed here to compare for the first time the antiproliferative and estrogenic/antiestrogenic effects of dietary polyphenols and microbiota-derived metabolites (i.e., resveratrol, dihydroresveratrol, urolithins (A, B, and Isourolithin A), and the flavanone hesperetin), with those effects exerted by their physiologically relevant glucuronides and sulfates on human BC cell lines (MDA-MB-231 and MCF-7). "

Related Drugs and Biologics

1.	Polyphenols
2.	Glucuronides
3.	Sulfates (Sulfates, Inorganic)
4.	Resveratrol
5.	dihydroresveratrol
6.	flavanone
7.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
8.	hesperetin
9.	urolithin B