ND-646

an acetyl-CoA carboxylase inhibitor with antineoplastic activity; structure in first source

Also Known As:

1,4-dihydro-1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-alpha,alpha,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno(2,3-d)pyrimidine-3(2H)-acetamide

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - ND-646: 4
  - Thiophenes: 257
    - ND-646: 4
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - ND-646: 4

Experts

1.	Chen, Shuibing: 1 article (11/2021)
2.	Duan, Xiaohua: 1 article (11/2021)
3.	Evans, Todd: 1 article (11/2021)
4.	Ho, David D: 1 article (11/2021)
5.	Huang, Yaoxing: 1 article (11/2021)
6.	Nair, Manoj S: 1 article (11/2021)
7.	Qiu, Yunping: 1 article (11/2021)
8.	Schwartz, Robert E: 1 article (11/2021)
9.	Tang, Xuming: 1 article (11/2021)
10.	Wang, Hui: 1 article (11/2021)

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/01/2019 - "Collectively, these findings indicate that ACC1 is a potential biomarker and target for non-small-cell lung cancer, and ND-646 and its derivatives as ACC1 inhibitors deserve further study for treatment of NSCLC."
2.	Neoplasms (Cancer) 10/01/2016 - "Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. " 01/01/2023 - "Furthermore, nortriptyline alone or in combination with ND-646, a selective ACC1/2 inhibitor, significantly repressed tumor growth, lipogenesis, and hepatic steatosis in mice. " 09/01/2019 - "Synthesis and anti-cancer activity of ND-646 and its derivatives as acetyl-CoA carboxylase 1 inhibitors." 10/01/2016 - "When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. "
3.	COVID-19 11/09/2021 - "Finally, xanthohumol, 5-(tetradecyloxy)-2-furoic acid, and ND-646, three compounds that suppress fatty acid biosynthesis, also block SARS-CoV-2 infection. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Carboplatin (JM8)
3.	Nortriptyline (Aventyl)
4.	Fatty Acids (Saturated Fatty Acids)
5.	Acetyl-CoA Carboxylase
6.	xanthohumol
7.	5-(tetradecyloxy)-2-furancarboxylic acid (TOFA)