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2- ((3- acrylamido- 4- methylphenyl)amino)- N- (2- methyl- 5- (3,4,5- trimethoxybenzamido)phenyl)- 4- (methylamino)pyrimidine- 5- carboxamide

type II irreversible bone marrow kinase in the X chromosome (BMX) kinase inhibitor; structure in first source

Also Known As:

CHMFL-BMX-078

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 2-((3-acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide: 1

Experts

1.	Chen, XiSha: 1 article (01/2022)
2.	Cheng, Yan: 1 article (01/2022)
3.	Fei, JiangFeng: 1 article (01/2022)
4.	Huang, HanXue: 1 article (01/2022)
5.	Jiang, ShiLong: 1 article (01/2022)
6.	Jiang, Ting: 1 article (01/2022)
7.	Li, LanYa: 1 article (01/2022)
8.	Liu, Chong: 1 article (01/2022)
9.	Liu, ZhaoQian: 1 article (01/2022)
10.	Wang, ZhiBin: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/05/2022 - "The BMX inhibitor CHMFL-BMX-078 could significantly suppress proliferation and induce cell cycle arrest in vemurafenib resistant melanoma cell line A375 (A375R), however, it was hypotoxic in immortal keratinocytes, melanoma cells, and other solid cancer cells such as glioma and breast cancer cells. "
2.	Melanoma (Melanoma, Malignant) 01/05/2022 - "In conclusion, these findings reveal that the BMX inhibitor CHMFL-BMX-078 may reverse vemurafenib resistance in melanoma by suppressing the AKT signaling pathway, implying that CHMFL-BMX-078 may be a promising compound for overcoming vemurafenib resistance." 01/05/2022 - "CHMFL-BMX-078, a BMX inhibitor, overcomes the resistance of melanoma to vemurafenib via inhibiting AKT pathway." 01/05/2022 - "The BMX inhibitor CHMFL-BMX-078 could significantly suppress proliferation and induce cell cycle arrest in vemurafenib resistant melanoma cell line A375 (A375R), however, it was hypotoxic in immortal keratinocytes, melanoma cells, and other solid cancer cells such as glioma and breast cancer cells. "
3.	Glioma (Gliomas) 01/05/2022 - "The BMX inhibitor CHMFL-BMX-078 could significantly suppress proliferation and induce cell cycle arrest in vemurafenib resistant melanoma cell line A375 (A375R), however, it was hypotoxic in immortal keratinocytes, melanoma cells, and other solid cancer cells such as glioma and breast cancer cells. "
4.	Breast Neoplasms (Breast Cancer) 01/05/2022 - "The BMX inhibitor CHMFL-BMX-078 could significantly suppress proliferation and induce cell cycle arrest in vemurafenib resistant melanoma cell line A375 (A375R), however, it was hypotoxic in immortal keratinocytes, melanoma cells, and other solid cancer cells such as glioma and breast cancer cells. "

Related Drugs and Biologics

1.	Vemurafenib