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TAM16 compound

a polyketide synthase 13 inhibitor with antitubercular activity; structure in first source

Also Known As:

5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-(piperidin-1-ylmethyl)benzofuran-3-carboxamide; TAM16

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - TAM16 compound: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - TAM16 compound: 1

Experts

1.	Aggarwal, Anup: 1 article (07/2017)
2.	Böttger, Erik C: 1 article (07/2017)
3.	Dhakal, Ramesh C: 1 article (07/2017)
4.	Dutta, Noton K: 1 article (07/2017)
5.	Epemolu, Ola: 1 article (07/2017)
6.	Floyd, David: 1 article (07/2017)
7.	Galaviz, Stacy: 1 article (07/2017)
8.	Hastings, Courtney: 1 article (07/2017)
9.	Ioerger, Thomas R: 1 article (07/2017)
10.	Karakousis, Petros C: 1 article (07/2017)

Related Diseases

1.

07/13/2017 - "TAM16 has excellent pharmacological and safety profiles, and the frequency of resistance for TAM16 is ∼100-fold lower than INH, suggesting that it can be developed as a new antitubercular aimed at the acute infection. "
07/13/2017 - "In multiple mouse models of TB infection, TAM16 showed in vivo efficacy equal to the first-line TB drug isoniazid, both as a monotherapy and in combination therapy with rifampicin. "

Related Drugs and Biologics

1.	Rifampin (Rifampicin)
2.	Isoniazid (Ftivazide)

Related Therapies and Procedures

1.	Therapeutics