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7- glutathione- 6,7- dihydro- 7- hydroxy- 1- hydroxymethyl- 5H- pyrrolizine

a pyrrolizidine alkaloid metabolite that forms adducts with DNA; structure in first source

Also Known As:

7-glutathione-DHP

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Glutathione: 14524
      - 7-glutathione-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine: 2
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Pyrrolizidine Alkaloids: 290
    - 7-glutathione-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pyrrolizidine Alkaloids: 290
      - 7-glutathione-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine: 2

Experts

1.	Fu, Peter P: 2 articles (01/2020 - 01/2017)
2.	He, Xiaobo: 2 articles (01/2020 - 01/2017)
3.	Xia, Qingsu: 2 articles (01/2020 - 01/2017)
4.	Lin, Ge: 1 article (01/2020)
5.	Shi, Qiang: 1 article (01/2020)

Related Diseases

1.

Neoplasms (Cancer)

01/01/2020 - "We previously determined that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP), 7-glutathione-DHP, 7-cysteine-DHP, 7-N-acetylcysteine-DHP, and 1-CHO-DHP are DNA reactive pyrrolic metabolites potentially associated with PA-induced liver tumor initiation. "
01/01/2017 - "These results suggest that 7-glutathione-DHP and 7-cysteine-DHP are reactive metabolites of PAs that can bind to cellular DNA to form DHP-DNA adducts in HepG2 cells, and can potentially initiate liver tumor formation."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	7- cysteine- 6,7- dihydro- 7- hydroxy- 1- hydroxymethyl- 5H- pyrrolizine
3.	DNA Adducts
4.	1-CHO-DHP