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decyltriphenylphosphonium

a mitochondrial-targeting agent

Also Known As:

10-TPP cpd; decyl-triphenylphosphonium

Networked: 13 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - decyltriphenylphosphonium: 13
- Onium Compounds
  - decyltriphenylphosphonium: 13

Experts

1.	Egorov, M V: 2 articles (04/2017 - 12/2008)
2.	Murphy, Michael P: 2 articles (05/2014 - 08/2009)
3.	Smith, Robin A J: 2 articles (05/2014 - 08/2009)
4.	Skulachev, V P: 2 articles (07/2012 - 12/2008)
5.	Aldossary, Hayyaf S: 1 article (05/2021)
6.	Alzahrani, Abdulaziz A: 1 article (05/2021)
7.	Batis, Nikolaos: 1 article (05/2021)
8.	Coney, Andrew M: 1 article (05/2021)
9.	Holmes, Andrew P: 1 article (05/2021)
10.	Kumar, Prem: 1 article (05/2021)

Related Diseases

1.	Arthritis (Polyarthritis) 01/01/2016 - "Efficacy of Mitochondrial Antioxidant Plastoquinonyl-decyl-triphenylphosphonium Bromide (SkQ1) in the Rat Model of Autoimmune Arthritis." 01/01/2016 - "In this study, a novel mitochondria-targeted antioxidant, plastoquinonyl-decyl-triphenylphosphonium bromide (SkQ1), was tested in vivo to prevent and cure experimental autoimmune arthritis. "
2.	Dry Eye Syndromes (Dry Eye Syndrome) 07/01/2012 - "Clinical trials of SkQ1 (plastoquinonyl decyltriphenylphosphonium) have been successfully completed so that the Ministry of Health of the Russian Federation recommends drops of very dilute (0.25 µM) solution of this antioxidant as a medicine to treat the syndrome of dry eye, which was previously considered an incurable disease developing with age. "
3.	Wounds and Injuries (Trauma) 05/01/2015 - "This study assesses a protective effect of a mitochondria-targeted antioxidant SkQT1 (a mixture of 10-(6'-toluquinonyl) decyltriphenylphosphonium and 10-(5'-toluquinonyl) decyltriphenylphosphonium in proportion of 1.4:1), using an open focal trauma model of the rat brain sensorimotor cortex and a model of amyloid-beta1-42 (Abeta)-induced impairment of hippocampal long-term potentiation (LTP), a kind of synaptic plasticity associated with learning and memory. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 05/01/2014 - "To further explore the hypothesis that mitochondrial dysfunction and nitroxidative stress contribute to disease pathogenesis at the in vivo level, we assessed whether the mitochondria-targeted antioxidant [10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenylphosphonium methane sulfonate (MitoQ) can modify disease progression in the SOD1(G93A) mouse model of ALS. " 01/01/2023 - "In vitro experiments revealed that administration of SFTSV or SFTSV glycoprotein (Gn) increased activation, apoptosis, ROS production, and mitochondrial dysfunction in separated mouse platelets, which could be effectively ameliorated by the application of antioxidants (NAC (N-acetyl-l-cysteine), SKQ1 (10-(6'-plastoquinonyl) decyltriphenylphosphonium) and resveratrol). "
5.	Stroke (Strokes) 08/01/2009 - "Eight-week-old male stroke-prone spontaneously hypertensive rats were treated with MitoQ(10) (500 mumol/L; n=16), control compound decyltriphenylphosphonium (decylTPP; 500 mumol/L; n=8), or vehicle (n=9) in drinking water for 8 weeks. " 12/01/2008 - "Effects of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) and 10-(6'-plastoquinonyl) decylrhodamine 19 (SkQR1) on rat models of H2O2- and ischemia-induced heart arrhythmia, heart infarction, kidney ischemia, and stroke have been studied ex vivo and in vivo. "

Related Drugs and Biologics

1.	Antioxidants
2.	Bromides
3.	Solutions
4.	mitoquinone
5.	Drinking Water
6.	Streptozocin (Streptozotocin)
7.	Plastoquinone
8.	Glycoproteins (Glycoprotein)
9.	Free Radicals
10.	Deoxyglucose (2 Deoxy D glucose)