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EED226

a polycomb repressive complex 2 inhibitor; structure in first source

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - EED226: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - EED226: 5

Experts

1.	Atadja, Peter: 2 articles (01/2022 - 01/2017)
2.	Chen, Zijun: 2 articles (01/2022 - 01/2017)
3.	Fang, Douglas: 2 articles (01/2022 - 01/2017)
4.	Feng, Lijian: 2 articles (01/2022 - 01/2017)
5.	Gu, Justin: 2 articles (01/2022 - 01/2017)
6.	Huang, Ying: 2 articles (01/2022 - 01/2017)
7.	Li, En: 2 articles (01/2022 - 01/2017)
8.	Li, Ling: 2 articles (01/2022 - 01/2017)
9.	Lingel, Andreas: 2 articles (01/2022 - 01/2017)
10.	Luo, Fangjun: 2 articles (01/2022 - 01/2017)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 01/01/2022 - "In this study, we investigated the role and underlying mechanism of the PRC2 in acute kidney injury (AKI) by using EED226, a highly selective PRC2 inhibitor, to target EED. "
2.	Neoplasms (Cancer) 01/01/2022 - "Previously, we have shown that binding of the low-molecular-weight compound EED226 to the H3K27me3 binding pocket of the regulatory subunit EED can effectively inhibit PRC2 activity in cells and reduce tumor growth in mouse xenograft models. " 01/01/2017 - "Together, we show that EED226 inhibits PRC2 activity via an allosteric mechanism and offers an opportunity for treatment of PRC2-dependent cancers." 01/01/2020 - "Since MHC-I genes alterations are found in a third of NPC tumors, the effect of EED226 on MHC-I genes expression on response to immunotherapy in NPC warrants further investigations." 01/01/2017 - "EED226 shows similar activity to SAM-competitive inhibitors in blocking H3K27 methylation of PRC2 target genes and inducing regression of human lymphoma xenograft tumors. "
3.	Lymphoma (Lymphomas) 01/01/2017 - "EED226 shows similar activity to SAM-competitive inhibitors in blocking H3K27 methylation of PRC2 target genes and inducing regression of human lymphoma xenograft tumors. "
4.	Colonic Neoplasms (Colon Cancer) 01/01/2020 - "Preliminary data also show that HCT-116 colon cancer cells, in which hMATE1 is epigenetically repressed, can be sensitized to compound 1 by priming the cells with the drugs EPZ-6438 (tazemetostat) and EED226. "

Related Drugs and Biologics

1.	tazemetostat

Related Therapies and Procedures

1.	Immunotherapy