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SPA3015

synthetic antineoplastic ajoene analog; structure in first source

Also Known As:

(E)-1-phenyl-7-phenyl-2,3,7-trithiahepta-4-ene 7-oxide

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Sulfides: 1062
        Disulfides: 2363
        SPA3015: 1
- Sulfur Compounds: 278
  - Hydrogen Sulfide: 2764
    - Sulfides: 1062
      - Disulfides: 2363
        SPA3015: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfides: 1062
    - Disulfides: 2363
      - SPA3015: 1

Experts

1.	Bae, Gyu-Un: 1 article (10/2016)
2.	Cho, Hyewon: 1 article (10/2016)
3.	Hwang, Jee Won: 1 article (10/2016)
4.	Jeon, Raok: 1 article (10/2016)
5.	Jeon, Youngsic: 1 article (10/2016)
6.	Kim, Su-Nam: 1 article (10/2016)
7.	Kim, Yong Kee: 1 article (10/2016)
8.	Lee, Jae Yeon: 1 article (10/2016)
9.	Lee, Sang Jin: 1 article (10/2016)
10.	Yoon, Sungpil: 1 article (10/2016)

Related Diseases

1.

Neoplasms (Cancer)

10/01/2016 - "Our findings support the hypothesis that SPA3015 inhibits NF-κB transcriptional activity by facilitating the physical interaction of the p65 subunit and PPARγ, which leads to apoptotic cell death in MDR cancer cells. "
10/01/2016 - "In this study, we investigated the anticancer effects of SPA3015, a synthetic ajoene analog, in P-gp-overexpressing MDR cancer cells (KBV20C and MES-SA/DX5). "
10/01/2016 - "The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells."

Related Drugs and Biologics

1.	ajoene