Thyroid Nuclear Factor 1

A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.

Also Known As:

Homeobox Protein Nkx-2.1; NK2 Homeobox 1 Protein; TITF-1 Protein; TITF1 Protein; TTF-1 Thyroid Nuclear Factor; Thyroid Transcription Factor 1; Thyroid-Specific Enhancer-Binding Protein; Enhancer-Binding Protein, Thyroid-Specific; Homeobox Protein Nkx 2.1; Nkx-2.1, Homeobox Protein; TITF 1 Protein; TTF 1 Thyroid Nuclear Factor; Thyroid Specific Enhancer Binding Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Thyroid Nuclear Factor 1: 346
  - Nuclear Proteins: 2678
    - Thyroid Nuclear Factor 1: 346
  - DNA-Binding Proteins: 2009
    - Homeodomain Proteins: 350
      - Thyroid Nuclear Factor 1: 346

rat Nkx2-1 protein

Bio-Agent Context: Research Results