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((ENB-3-isopropoxy-PIDMP)Ga(III))

used to monitor the activity of breast cancer resistance protein; structure in first source

Also Known As:

67Ga-Galmydar; 68Ga-Galmydar; Galmydar

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Coordination Complexes: 576
  - ((ENB-3-isopropoxy-PIDMP)Ga(III)): 4
Organic Chemicals: 133
- Coordination Complexes: 576
  - ((ENB-3-isopropoxy-PIDMP)Ga(III)): 4

Experts

1.	Sharma, Vijay: 4 articles (01/2020 - 03/2016)
2.	Sivapackiam, Jothilingam: 4 articles (01/2020 - 03/2016)
3.	Sharma, Monica: 2 articles (01/2020 - 01/2019)
4.	Laforest, Richard: 2 articles (01/2019 - 01/2018)
5.	Schindler, Thomas H: 1 article (01/2020)
6.	Kabra, Shivesh: 1 article (01/2019)
7.	Rettig, Michael P: 1 article (01/2019)
8.	Salter, Amber: 1 article (01/2019)
9.	Speidel, Sylvia: 1 article (01/2019)
10.	Harpstrite, Scott E: 1 article (03/2016)

Related Diseases

1.	Cardiotoxicity 01/01/2020 - "Given that electrochemical gradient changes at the mitochondrial membrane represent an upstream, and earliest event before triggering the production of the ROS and caspase activity in a biochemical cascade, the former category might offer interrogation of cardiotoxicity at earliest stages exemplified by PET imaging, using 18F-Mitophos and 68Ga-Galmydar in rodent models. " 01/01/2019 - "68Ga-Galmydar: A PET imaging tracer for noninvasive detection of Doxorubicin-induced cardiotoxicity."
2.	Breast Neoplasms (Breast Cancer) 03/01/2016 - "(67/68)Galmydar: A metalloprobe for monitoring breast cancer resistance protein (BCRP)-mediated functional transport activity." 01/01/2018 - "68Ga[Ga]-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells. "
3.	Neoplasms (Cancer) 01/01/2018 - "68Ga[Ga]-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells. "
4.	Cardiomyopathies (Cardiomyopathy) 01/01/2019 - "To assess 68Ga-Galmydar ability for monitoring DOX-induced cardiomyopathy, microPET imaging was performed 5 d post treatment of rats either with a single dose of DOX (15 mg/kg) or vehicle as a control (saline) and images were co-registered for anatomical reference using CT. " 01/01/2019 - "Herein, we report a preliminary investigation of 68Ga-Galmydar potential to monitor Dox-induced cardiomyopathy in vivo, ex vivo, and in cellulo employing both nuclear- and optical imaging. "
5.	Carcinoma (Carcinomatosis) 01/01/2018 - "68Ga[Ga]-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells. "

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