HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

ADX71743

an mGlu7 negative allosteric modulator; structure in first source

Also Known As:

6-(2,4-dimethylphenyl)-2-ethyl-6,7-dihydrobenzo(d)oxazol-4(5H)-one

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxazoles: 68
      - ADX71743: 3

Experts

1.	Kalinichev, Mikhail: 2 articles (01/2015 - 03/2013)
2.	Boccella, Serena: 1 article (01/2018)
3.	Farina, Antonio: 1 article (01/2018)
4.	Guida, Francesca: 1 article (01/2018)
5.	Iannotta, Monica: 1 article (01/2018)
6.	Luongo, Livio: 1 article (01/2018)
7.	Maione, Sabatino: 1 article (01/2018)
8.	Marabese, Ida: 1 article (01/2018)
9.	Palazzo, Enza: 1 article (01/2018)
10.	Serra, Nicola: 1 article (01/2018)

Related Diseases

1.	Psychotic Disorders (Schizoaffective Disorder) 03/01/2013 - "Our in vivo tests using ADX71743, reported here, suggest that pharmacological inhibition of mGlu(7) is a valid approach for developing novel pharmacotherapies to treat anxiety disorders, but may not be suitable for treatment of depression or psychosis."
2.	Pain (Aches) 01/01/2015 - "ADX71743 reduced visceral hypersensitivity in the WKY rat as exhibited by increased visceral sensitivity threshold with concomitant reductions in total number of pain behaviours. "
3.	Hypersensitivity (Allergy) 01/01/2015 - "ADX71743 reduced visceral hypersensitivity in the WKY rat as exhibited by increased visceral sensitivity threshold with concomitant reductions in total number of pain behaviours. "
4.	Hyperalgesia 01/01/2018 - "The effect of AMN082 on mechanical allodynia and glutamate release was blocked by 6-(2,4-dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone (ADX71743), a selective mGluR7 negative allosteric modulator. "
5.	Central Nervous System Diseases (CNS Diseases) 03/01/2013 - "These data suggest that ADX71743 is a suitable compound to help unravel the physiologic role of mGlu(7) and to better understand its implication in central nervous system diseases. "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride
3.	metabotropic glutamate receptor 7

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)