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17- cyclopropylmethyl- 3- hydroxy- 4,5- epoxy- 7,8- en- 6- ((3'- iodo)benzamido)morphinan

a dual kappa and delta opioid receptor agonist with antinociceptive activity; structure in first source

Also Known As:

MP1104

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - Morphinans: 33
      - 17-cyclopropylmethyl-3-hydroxy-4,5-epoxy-7,8-en-6-((3'-iodo)benzamido)morphinan: 2

Experts

1.	Majumdar, Susruta: 2 articles (01/2021 - 01/2020)
2.	Uprety, Rajendra: 2 articles (01/2021 - 01/2020)
3.	Alder, Amy Frances: 1 article (01/2021)
4.	Atigari, Diana Vivian: 1 article (01/2021)
5.	Kivell, Bronwyn Maree: 1 article (01/2021)
6.	Miller, John H: 1 article (01/2021)
7.	Paton, Kelly Frances: 1 article (01/2021)
8.	Scouller, Brittany: 1 article (01/2021)
9.	Váradi, András: 1 article (01/2021)
10.	Damaj, M Imad: 1 article (01/2020)

Related Diseases

1.	Pain (Aches) 01/01/2020 - "These findings support the development of MP1104 for further testing in other pain models." 01/01/2020 - "In this study, we investigated MP1104 in the formalin test, a model of tonic pain. " 01/01/2020 - "MP1104 (0.05, 0.1, and 1.0 mg/kg) reduced pain-like behaviors in phases I and II of the formalin test in male and female ICR mice. "
2.	Respiratory Insufficiency (Respiratory Failure) 01/01/2021 - "Moreover, MP1104 did not induce sedative effects in the open-field locomotor activity test, respiratory depression in mice using whole-body plethysmography, or have cross-tolerance with morphine. "
3.	Neuralgia (Stump Neuralgia) 01/01/2021 - "The mixed kappa and delta opioid receptor agonist, MP1104, attenuates chemotherapy-induced neuropathic pain." 01/01/2021 - "In the paclitaxel-induced neuropathic pain model in mice, MP1104 reduced both mechanical and cold allodynia and unlike morphine, did not produce tolerance when administered daily for 23 days. "
4.	Hyperalgesia 01/01/2021 - "In the paclitaxel-induced neuropathic pain model in mice, MP1104 reduced both mechanical and cold allodynia and unlike morphine, did not produce tolerance when administered daily for 23 days. "

Related Drugs and Biologics

1.	Formaldehyde (Formol)
2.	delta Opioid Receptors (delta Opioid Receptor)
3.	Paclitaxel (Taxol)
4.	Morphine (MS Contin)
5.	Hypnotics and Sedatives (Sedatives)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)