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68Ga-aquibeprin

a PET radiotracer for imaging alpha5beta1 and alphavbeta3 integrins; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hoffmann, Frauke: 1 article (10/2016)
2.	Kessler, Horst: 1 article (10/2016)
3.	Notni, Johannes: 1 article (10/2016)
4.	Reich, Dominik: 1 article (10/2016)
5.	Schwaiger, Markus: 1 article (10/2016)
6.	Steiger, Katja: 1 article (10/2016)
7.	Wester, Hans-Jürgen: 1 article (10/2016)

Related Diseases

1.

Neoplasms (Cancer)

10/01/2016 - "The highest tumor-to-tissue ratios were observed both in ex vivo biodistribution and PET for comparably large doses, for example, 6 nmol (0.65 mg/kg) 68Ga-aquibeprin per mouse (3.5 MBq/nmol). "
10/01/2016 - "For mass doses (specific activities) of less than 20 pmol (>1,000 MBq/nmol) and 1 nmol (20 MBq/nmol) per mouse, respectively, uptake of 68Ga-aquibeprin and 68Ga-avebetrin in M21 tumors dropped from 5.3 and 3.5 to 3.0 and 2.4 percentage injected dose per gram (%ID/g), respectively. "
10/01/2016 - "Presumably because of their high affinities, 68Ga-aquibeprin and 68Ga-avebetrin allow for selective addressing of target sites with different integrin expression levels by virtue of adjusting specific activity, which can be exploited for visualization of low-level target expression or optimization of tumor-to-background contrast."

Related Drugs and Biologics

1.	Integrins
2.	68Ga-avebetrin