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BJ-1108

an angiogenesis inhibitor with antineoplastic activity; structure in first source

Networked: 3 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - BJ-1108: 3
  - Aniline Compounds: 46
    - BJ-1108: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - BJ-1108: 3

Experts

1.	Jeong, Byeong-Seon: 3 articles (01/2021 - 01/2016)
2.	Nam, Tae-Gyu: 3 articles (01/2021 - 01/2016)
3.	Kim, Jung-Ae: 2 articles (01/2021 - 01/2016)
4.	Cho, Hyun Jung: 1 article (01/2021)
5.	Kim, Eun Soo: 1 article (01/2021)
6.	Kim, Sung Kook: 1 article (01/2021)
7.	Lee, Hoyul: 1 article (01/2021)
8.	Lee, Joon Seop: 1 article (01/2021)
9.	Lee, Yu-Jeong: 1 article (01/2021)
10.	Chang, Jae-Hoon: 1 article (02/2017)

Related Diseases

1.	Inflammation (Inflammations) 02/28/2017 - "BJ-1108 treatment ameliorates inflammation and EAE by inhibiting Th1 and Th17 cells differentiation. " 02/28/2017 - "Our findings suggest that BJ-1108 is a promising novel therapeutic agent for the treatment of inflammation and autoimmune disease." 01/01/2021 - "This study demonstrated that BJ-1108 ameliorated intestinal inflammation in an experimental colitis mouse model, suggesting possible therapeutic implications for IBD."
2.	Disease Progression 02/28/2017 - "Furthermore, in vivo studies showed that BJ-1108 delayed onset of disease and suppressed experimental autoimmune encephalomyelitis (EAE) disease progression by inhibiting differentiation of Th1 and Th17 cells. "
3.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 02/28/2017 - "BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis." 02/28/2017 - "Furthermore, in vivo studies showed that BJ-1108 delayed onset of disease and suppressed experimental autoimmune encephalomyelitis (EAE) disease progression by inhibiting differentiation of Th1 and Th17 cells. "
4.	Neoplasms (Cancer) 01/01/2016 - "In addition, BJ-1108 induced a significant reduction in the size and weight of excised tumors in breast cancer cell-inoculated CAM assay, showing proportionate suppression of tumor growth along with inhibition of angiogenesis. " 01/01/2016 - "BJ-1108, a 6-Amino-2,4,5-Trimethylpyridin-3-ol Analog, Inhibits Serotonin-Induced Angiogenesis and Tumor Growth through PI3K/NOX Pathway." 01/01/2016 - "In an effort to develop new molecularly targeted anticancer agents against 5-HT action in tumor growth, we demonstrate that BJ-1108, a derivative of 6-amino-2,4,5-trimethylpyridin-3-ol, significantly inhibited 5-HT-induced angiogenesis. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "In addition, BJ-1108 induced a significant reduction in the size and weight of excised tumors in breast cancer cell-inoculated CAM assay, showing proportionate suppression of tumor growth along with inhibition of angiogenesis. "

Related Drugs and Biologics

1.	Claudin-3
2.	Claudin-1
3.	Dextran Sulfate
4.	Serotonin (5 Hydroxytryptamine)
5.	Proteins (Proteins, Gene)
6.	Antineoplastic Agents (Antineoplastics)