SCH 546738

a CXCR3 antagonist; structure in first source

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

1.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/10/2012 - "SCH 546738 also significantly reduces disease severity in rat and mouse experimental autoimmune encephalomyelitis models. " 01/10/2012 - "In vivo efficacy of SCH 546738 was determined by mouse collagen-induced arthritis, rat and mouse experimental autoimmune encephalomyelitis, and rat cardiac transplantation models. "
2.	Experimental Arthritis 01/10/2012 - "SCH 546738 potently and specifically inhibits CXCR3-mediated chemotaxis in human activated T cells with IC90 about 10 nM. SCH 546738 attenuates the disease development in mouse collagen-induced arthritis model. " 01/10/2012 - "In vivo efficacy of SCH 546738 was determined by mouse collagen-induced arthritis, rat and mouse experimental autoimmune encephalomyelitis, and rat cardiac transplantation models. "
3.	Autoimmune Diseases (Autoimmune Disease) 01/10/2012 - "A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection."

1.	Heart Transplantation (Grafting, Heart)