physciosporin

11/28/2019 - "In this study, we found that a non-toxic concentration of physciosporin, a compound isolated from Pseudocyphellaria granulata, significantly decreased colony formation on soft agar and spheroid formation by CSC221 cancer stem-like cells. "
11/28/2019 - "Aldehyde dehydrogenase-1 (ALDH1), the most important cancer stem marker, was sharply downregulated at both the protein and mRNA level following treatment with physciosporin. "
01/05/2022 - "This review focuses on the lichen-derived metabolite gyrophoric acid and other select secondary metabolites (e.g., usnic acid, salazinic acid, physodic acid, vulpinic acid ceratinalone, flavicansone, ramalin, physciosporin, tumidulin, atranorin, parmosidone) that modulate a number of cellular pathways relevant to several biomedical diseases and disorders, including cancer, diabetes and cardiovascular disease. "

11/28/2019 - "Together, these results demonstrate for the first time that physciosporin is a potent inhibitor of colorectal cancer cell stemness."
11/28/2019 - "Physciosporin also decreased spheroid formation in other colorectal cancer cell lines, including DLD1, Caco2, and HT29. "
11/28/2019 - "Lichen Secondary Metabolite Physciosporin Decreases the Stemness Potential of Colorectal Cancer Cells."
03/15/2019 - "Physciosporin suppresses the proliferation, motility and tumourigenesis of colorectal cancer cells."
02/01/2021 - "Corrigendum to: 'Physciosporin suppresses the proliferation, motility and tumorigenesis of colorectal cancer cells' Phytomedicine 56 (2019) 10-20."

10/01/2021 - "Physciosporin suppresses mitochondrial respiration, aerobic glycolysis, and tumorigenesis in breast cancer."
02/01/2021 - "Corrigendum to: 'Physciosporin suppresses the proliferation, motility and tumorigenesis of colorectal cancer cells' Phytomedicine 56 (2019) 10-20."

03/15/2019 - "Physciosporin (PHY) is a potent secondary metabolite found in lichens and was recently reported to inhibit the motility of lung cancer cells via novel mechanisms. "
01/01/2015 - "These results demonstrated that the lichen secondary metabolite, physciosporin, inhibits lung cancer cell motility through novel mechanisms of action. "
01/01/2015 - "Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility."

01/01/2015 - "Quantitative real-time PCR analysis showed that the expression of the metastasis suppressor gene, KAI1, was increased while that of the metastasis enhancer gene, KITENIN, was dramatically decreased by physciosporin. "