CX-6258

a Pim kinase inhibitor; (11C)CX-6258 is a PET radiotracer for imaging Pim kinases; structure in first source

Also Known As:

(11C)CX-6258; 5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Ewing Sarcoma (Sarcoma, Ewing) 01/01/2020 - "Furthermore, the activity of CX-6258 was validated in several Ewing sarcoma and multiple myeloma cell lines. "
2.	Prostatic Neoplasms (Prostate Cancer) 11/15/2016 - "CX-5461 and CX-6258, a pan-PIM kinase inhibitor, were tested alone and in combination in prostate cancer cell lines, in Hi-MYC- and PTEN-deficient mouse models and in patient-derived xenografts (PDX) of metastatic tissue obtained from a patient with castration-resistant prostate cancer. "
3.	Neoplasms (Cancer) 01/01/2020 - "In murine models, CX-6258 induced a potent cGAS-dependent type-I IFN response in tumor cells, increased IFNγ-producing CD8+ T cells, and reduced Treg frequency in vivo. " 01/01/2020 - "SIGNIFICANCE: HASPIN inhibition by CX-6258 is a novel and potent strategy for RAF/MEK inhibitor-resistant melanoma and potentially other tumor types. "
4.	Multiple Myeloma 01/01/2020 - "Furthermore, the activity of CX-6258 was validated in several Ewing sarcoma and multiple myeloma cell lines. "
5.	Melanoma (Melanoma, Malignant) 01/01/2020 - "We report that the small-molecule CX-6258 has potent activity against both RMi-sensitive (RMS) and -resistant (RMR) melanoma cell lines. " 01/01/2020 - "SIGNIFICANCE: HASPIN inhibition by CX-6258 is a novel and potent strategy for RAF/MEK inhibitor-resistant melanoma and potentially other tumor types. "

1.	Mitogen-Activated Protein Kinase Kinases (MEKs)
2.	Phosphotransferases (Kinase)
3.	CX 5461
4.	osimertinib

1.	Castration