DSM265

01/01/2017 - "Future trials are needed to investigate further the use of DSM265 for the prophylaxis of malaria. "
11/01/2019 - "These findings underscore the importance of developing DSM265 as part of a combination therapy with other agents for successful use against malaria."
12/20/2019 - "Artefenomel and DSM265 are two new compounds that have been shown to be well tolerated and effective when administered as monotherapy malaria treatment. "
01/01/2017 - "Healthy participants aged 18-55 years were enrolled in a two-part study: part 1, a single ascending dose (25-1200 mg), double-blind, randomised, placebo-controlled study, and part 2, an open-label, randomised, active-comparator controlled study, in which participants were inoculated with Plasmodium falciparum induced blood-stage malaria (IBSM) and treated with DSM265 (150 mg) or mefloquine (10 mg/kg). "
01/01/2016 - "DHODH is a validated target for malaria, and DSM265, a potent inhibitor, is currently in clinical trials. "

01/01/2018 - "This study aimed to assess the efficacy of DSM265 in patients with P falciparum or Plasmodium vivax malaria infection. "
01/01/2018 - "A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation."
01/01/2017 - "DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection."
12/20/2019 - "This study aimed to determine the safety, pharmacokinetics, and pharmacodynamics of artefenomel and DSM265 administered in combination to healthy subjects in a volunteer infection study using the Plasmodium falciparum-induced blood-stage malaria model. "
01/01/2017 - "We assessed the prophylactic activity of DSM265 against controlled human malaria infection (CHMI). "

01/01/2019 - "In a previous phase 1b study, a single 150-mg dose of DSM265 showed partial efficacy against experimentally induced blood-stage Plasmodium falciparum malaria (IBSM). "
12/01/2021 - "Data of healthy volunteers infected with falciparum malaria collected from four trials (three that administered OZ439 and DSM265 alone, and the fourth a combination of OZ439 and DSM265) were analysed. "
01/01/2018 - "DSM265: a novel drug for single-dose cure of Plasmodium falciparum malaria."
12/01/2021 - "Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria."
12/20/2019 - "The results of this single-dosing combination study support the further clinical development of the use of artefenomel and DSM265 in combination as a treatment for falciparum malaria. "

01/01/2018 - "This study aimed to assess the efficacy of DSM265 in patients with P falciparum or Plasmodium vivax malaria infection. "
01/01/2018 - "Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study."

01/01/2019 - "All other participants developed parasitemia, with the complete clearance of asexual parasites occurring following DSM265 treatment. "