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3,3',4,4'-tetrahydroxystilbene

has antineoplastic activity; structure in first source

Also Known As:

3,3',4,4'-THS; 3,3',4,4'-tetrahydroxy-trans-stilbene

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Catechols: 121
        3,3',4,4'-tetrahydroxystilbene: 2
        Benzylidene Compounds: 10
        Stilbenes: 657
        3,3',4,4'-tetrahydroxystilbene: 2

Experts

1.	Murias, Marek: 2 articles (01/2015 - 02/2014)
2.	Wierzchowski, Marcin: 2 articles (01/2015 - 02/2014)
3.	Brewińska-Olchowik, Marta: 1 article (01/2015)
4.	Książek, Krzysztof: 1 article (01/2015)
5.	Mikuła-Pietrasik, Justyna: 1 article (01/2015)
6.	Piwocka, Katarzyna: 1 article (01/2015)
7.	Sosińska, Patrycja: 1 article (01/2015)
8.	Szpurek, Dariusz: 1 article (01/2015)
9.	Dudka, Jaroslaw: 1 article (02/2014)
10.	Jäger, Walter: 1 article (02/2014)

Related Diseases

1.	T-Cell Leukemia (Leukemia, T Cell) 02/25/2014 - "In present study the effects of resveratrol (Res) and its three derivatives: 3,3',4,4'-tetrahydroxy-trans-stilbene (M6), 3,4,4',5-tetrahydroxy-trans-stilbene (M8) and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene (M12) were investigated on T cell leukemia Jurkat cells. "
2.	Neoplasms (Cancer) 01/01/2015 - "The study showed that 3,3',4,4'-THS affects cancer cell viability much more efficiently than its parent drug. " 01/01/2015 - "Collectively, our findings indicate that 3,3',4,4'-THS may constitute a valuable tool in the fight against ovarian malignancy and that the anticancer capabilities of this stilbene proceed in an oxidative stress-dependent mechanism. " 01/01/2015 - "This effect coincided with increased generation of reactive oxygen species, downregulated activity of superoxide dismutase and catalase, and excessive accumulation of 8-hydroxy-2'-deoxyguanosine and its insufficient repair due to decreased expression of DNA glycosylase I. Cytotoxicity elicited by 3,3',4,4'-THS was related to increased incidence of apoptosis, which was mediated by caspases 3 and 9. Moreover, 3,3',4,4'-THS inhibited cancer cell proliferation and accelerated senescence, which was accompanied by the activation of p38 MAPK. "
3.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2015 - "We explored the effect of a new resveratrol (RVT) derivative, 3,3',4,4'-tetrahydroxy-trans-stilbene (3,3',4,4'-THS), on viability, apoptosis, proliferation, and senescence of three representative lines of ovarian cancer cells, that is, A2780, OVCAR-3, and SKOV-3, in vitro. " 01/01/2015 - "High Potency of a Novel Resveratrol Derivative, 3,3',4,4'-Tetrahydroxy-trans-stilbene, against Ovarian Cancer Is Associated with an Oxidative Stress-Mediated Imbalance between DNA Damage Accumulation and Repair."

Related Drugs and Biologics

1.	Resveratrol
2.	3,3',4,4',5,5'-hexahydroxystilbene
3.	p38 Mitogen-Activated Protein Kinases
4.	DNA Glycosylases (DNA Glycosylase)
5.	Caspases
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Superoxide Dismutase
8.	Stilbenes
9.	Catalase
10.	8-Hydroxy-2'-Deoxyguanosine