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CCT251545

a Wnt signaling inhibitor; structure in first source

Also Known As:

8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro(4.5)decan-1-one

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - CCT251545: 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - CCT251545: 2
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - CCT251545: 2

Experts

1.	Adeniji-Popoola, Olajumoke: 1 article (12/2015)
2.	Blagg, Julian: 1 article (12/2015)
3.	Blaukat, Andree: 1 article (12/2015)
4.	Box, Gary: 1 article (12/2015)
5.	Clarke, Paul A: 1 article (12/2015)
6.	Court, Will: 1 article (12/2015)
7.	Czodrowski, Paul: 1 article (12/2015)
8.	Dale, Trevor: 1 article (12/2015)
9.	Eccles, Suzanne A: 1 article (12/2015)
10.	Esdar, Christina: 1 article (12/2015)

Related Diseases

1.

Neoplasms (Cancer)

12/01/2015 - "Finally, we demonstrate in vivo activity of CCT251545 in WNT-dependent tumors. "
01/01/2023 - "Using a patient-derived organoid (PDO)-based drug screening platform, we report that the combined use of chemotherapy and CCT251545 (CCT) displays robust synergistic effect against PDOs and reduces proliferation of MDR cancer cells in vitro, and results in regression of xenograft tumors, reductions in metastatic dissemination and recurrence rate in vivo. "
01/01/2023 - "CCT251545 enhances drug delivery and potentiates chemotherapy in multidrug-resistant cancers by Rac1-mediated macropinocytosis."

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)