Kai-Xin-San

It has a combination of four herbs: Ginseng Radix et Rhizoma (GR; root and rhizome of Panax ginseng C. A. Mey.), Polygalae Radix (PR; root of Polygala tenuifolia Wild.), Acori Tatarinowii Rhizoma (ATR; rhizome of Acorus tatarinowii Schott), and Poria (PO; sclerotium of Poriacocos (Schw.) Wolf), has been widely used to treat mental depression and memory loss in China

Also Known As:

Networked: 41 relevant articles (9 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhu, Yue: 6 articles (01/2021 - 12/2016)
2.	Liu, Ping: 5 articles (12/2021 - 01/2012)
3.	Duan, Jin-Ao: 5 articles (01/2021 - 12/2016)
4.	Bi, Kaishun: 5 articles (01/2019 - 08/2013)
5.	Li, Qing: 5 articles (01/2019 - 08/2013)
6.	Hu, Yuan: 4 articles (12/2021 - 01/2012)
7.	Cao, Cheng: 4 articles (01/2021 - 06/2018)
8.	Huang, Fei: 3 articles (01/2021 - 12/2016)
9.	Liu, Mengqiu: 3 articles (01/2021 - 10/2018)
10.	Huang, Renjie: 3 articles (10/2020 - 06/2018)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 04/01/2020 - "A metabolomic study of the urine of rats with Alzheimer's disease and the efficacy of Ding-Zhi-Xiao-Wan on the afflicted rats." 01/01/2019 - "Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer's Disease Based on Systems Biology." 05/01/2017 - "Ultra-fast liquid chromatography with tandem mass spectrometry determination of eight bioactive components of Kai-Xin-San in rat plasma and its application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats." 05/01/2023 - "To explore the specific pharmacological molecular mechanisms of Kai Xin San (KXS) on treating Alzheimer's disease (AD) based on network pharmacology and experimental validation. " 05/01/2023 - "Therapeutic Mechanism of Kai Xin San on Alzheimer's Disease Based on Network Pharmacology and Experimental Validation."
2.	Cognitive Dysfunction 06/01/2023 - "Kai-Xin-San (KXS) has been reported to be effective in improving cognitive impairment in AD. " 01/01/2023 - "Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice." 05/01/2019 - "Kai Xin San (KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. " 07/01/2009 - "Kai Xin San (KXS), a traditional Chinese herbal medicine, has been used clinically for the treatment of depressive disorders and cognitive impairment for centuries. " 05/01/2019 - "Kai Xin San ameliorates scopolamine-induced cognitive dysfunction."
3.	Inflammation (Inflammations) 01/01/2021 - "Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-Induced Depression-like Mice and Reduces the Expressions of Inflammatory Factors via Inhibiting TLR4/IKK/NF-κB Pathways on BV2 Cells." 10/28/2020 - "Chinese medicine formula Kai-Xin-San ameliorates depression-like behaviours in chronic unpredictable mild stressed mice by regulating gut microbiota-inflammation-stress system." 01/01/2021 - "Kai-Xin-San Attenuates Doxorubicin-Induced Cognitive Impairment by Reducing Inflammation, Oxidative Stress, and Neural Degeneration in 4T1 Breast Cancer Mice."
4.	Anxiety Disorders (Anxiety Disorder) 01/31/2012 - "Kai Xin San (KXS) is a traditional Chinese herbal prescription for the treatment of depression-like disorders, anxiety, and impairment in learning and memory, however, there is very little scientific data concerning the efficacy of this. "
5.	Amnesia (Dissociative Amnesia) 01/01/2020 - "This study aimed to investigate the mechanisms of Kai-Xin-San (KXS, a famous Chinese herbal decoction used to treat amnesia) on the degradation of Aβ and further elucidate the mechanism of KXS on Aβ-induced memory dysfunction. " 07/01/2016 - "The traditional Chinese herbal formula Kai Xin San (KXS) has been used to treat amnesia for thousands years. " 05/01/2022 - "In light of the complex pathogenesis of AD, the traditional Chinese medicine (TCM) formula Kai-Xin-San (KXS), which was used for amnesia treatment, has been proved to improve cognitive function in AD animal models. " 12/05/2021 - "Kaixinsan (KXS) decoction, as an herbal formula, was used to treat the diseases, such as insomnia, amnesia, emotional disorders in ancient china. " 03/15/2016 - "Kai-Xin-San (KXS) is an herbal formulae that has been widely used to treat mental disorders, especially amnesia and depression in China. "

Related Drugs and Biologics

1.	Catenins
2.	Neurotransmitter Agents (Neurotransmitter)
3.	Scopolamine (Hyoscine)
4.	Proteins (Proteins, Gene)
5.	Amyloid (Amyloid Fibrils)
6.	Therapeutic Uses
7.	Doxorubicin (Adriamycin)
8.	Acids
9.	polygalaxanthone III
10.	Sirtuin 3

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Oral Administration