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SGC707

structure in first source

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - SGC707: 5

Experts

1.	Hoekstra, Menno: 2 articles (10/2022 - 01/2019)
2.	Van Eck, Miranda: 2 articles (10/2022 - 01/2019)
3.	de Jong, Laura M: 2 articles (10/2022 - 01/2019)
4.	Hankemeier, Thomas: 1 article (10/2022)
5.	Lindenburg, Peter W: 1 article (10/2022)
6.	Manson, Martijn L: 1 article (10/2022)
7.	Martins Cardoso, Renata: 1 article (10/2022)
8.	Salvatori, Daniela C F: 1 article (10/2022)
9.	Sijsenaar, Timothy J P: 1 article (10/2022)
10.	Zhang, Zhengzheng: 1 article (10/2022)

Related Diseases

1.	Atherosclerosis 01/01/2019 - "In contrast, the extent of in vivo macrophage foam cell formation and aortic root atherosclerosis was not affected by SGC707 treatment. " 01/01/2019 - "Here we validated the hypothesis that treatment with the allosteric PRMT3 inhibitor SGC707 will diminish the hepatic steatosis extent, while leaving global cholesterol metabolism, important in cholesterol-driven pathologies like atherosclerosis, untouched. "
2.	Embryo Loss 11/18/2021 - "In vivo experiments revealed that the administration of SGC707 reduced the embryo resorption rate of CBA/J × DBA/2 mice. " 11/18/2021 - "CBA/J × DBA/2 mouse models were used to investigate the effects of SGC707 on embryo resorption rates. "
3.	Pruritus (Itching) 10/01/2022 - "In conclusion, we have shown that SGC707 treatment reduces hepatic steatosis and plasma triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. " 10/01/2022 - "PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice."
4.	DNA Virus Infections 01/01/2023 - "Furthermore, mice with loss of one copy of Prmt3 or in vivo treatment of the PRMT3 inhibitor, SGC707, are more resistant to RNA and DNA virus infection. "
5.	Metabolic Bone Diseases (Osteopenia) 01/01/2019 - "Moreover, administration of Prmt3 shRNA or a chemical inhibitor of PRMT3 (SGC707) caused an osteopenia phenotype in mice. "

Related Drugs and Biologics

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3.	RNA (Ribonucleic Acid)
4.	LDL Receptors (LDL Receptor)
5.	Cholesterol