(5'- (4- amino- 7,7- dimethyl- 2- trifluoromethyl- 7H- pyrimido(4,5- b)(1,4)oxazin- 6- yl)- 2',3'- dihydrospiro(cyclohexane- 1,1'- inden)- 4- yl)acetic acid

an inhibitor of acyl-CoA-diacylglycerol transferase 1; structure in first source

Also Known As:

(trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid monobenzenesulfonate; JTT-553

Networked: 2 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ishii, Yukihito: 2 articles (09/2015 - 01/2015)
2.	Kakutani, Makoto: 2 articles (09/2015 - 01/2015)
3.	Ogawa, Nobuya: 2 articles (09/2015 - 01/2015)
4.	Ohta, Takeshi: 2 articles (09/2015 - 01/2015)
5.	Okuma, Chihiro: 2 articles (09/2015 - 01/2015)
6.	Tomimoto, Daisuke: 2 articles (09/2015 - 01/2015)
7.	Imanaka, Tsuneo: 1 article (09/2015)
8.	Kobayashi, Akio: 1 article (09/2015)
9.	Akiyama, Yoshiyuki: 1 article (01/2015)
10.	Ohkuma, Yoshiaki: 1 article (01/2015)

Related Diseases

1.	Obesity 01/01/2015 - "Therefore, JTT-553 is expected to be an effective novel therapeutic agent for the treatment of obesity." 09/01/2015 - "JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice." 09/01/2015 - "JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase 1 inhibitor, reduced body weight depending on dietary fat in diet-induced obesity (DIO) rats in our previous study. "
2.	Glucose Intolerance 09/01/2015 - "JTT-553 also improved insulin-dependent glucose uptake in adipose tissues and glucose intolerance in DIO mice. "
3.	Body Weight (Weight, Body) 09/01/2015 - "JTT-553 reduced body weight gain and fat weight in both mouse models. " 01/01/2015 - "JTT-553 exerted multiple effects on intestinal fat absorption, adipose fat synthesis, and food intake, and consequently induced body weight reduction. " 01/01/2015 - "Furthermore, JTT-553 reduced daily food intake and body weight gain in diet-induced obese rats after 4-week repeated administration. " 09/01/2015 - "Here, the effect of JTT-553 on glucose metabolism was evaluated using body weight reduction in T2DM mice. " 09/01/2015 - "These results suggest that JTT-553 improves insulin resistance in adipose tissues and systemic glucose metabolism through reductions in body weight. "
4.	Insulin Resistance 09/01/2015 - "These results suggest that JTT-553 improves insulin resistance in adipose tissues and systemic glucose metabolism through reductions in body weight. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	Diacylglycerol O-Acyltransferase
4.	Dietary Fats (Dietary Fat)
5.	Acyl Coenzyme A (Acyl CoA)