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SPL-334

inhibitor of S-nitrosoglutathione reductase

Also Known As:

4-((2-((2-cyanobenzyl)thio)-4-oxothieno(3,2-d)pyrimidin-3(4H)-yl)methyl)benzoic acid

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        SPL-334: 2
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - SPL-334: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - SPL-334: 2

Experts

1.	Atamas, Sergei P: 1 article (10/2015)
2.	Kopach, Pavel: 1 article (10/2015)
3.	Lockatell, Virginia: 1 article (10/2015)
4.	Luzina, Irina G: 1 article (10/2015)
5.	Pentikis, Helen S: 1 article (10/2015)
6.	Todd, Nevins W: 1 article (10/2015)
7.	Bassett, David J P: 1 article (01/2013)
8.	Bradley, Matthews O: 1 article (01/2013)
9.	Ferrini, Maria E: 1 article (01/2013)
10.	Jaffar, Zeina: 1 article (01/2013)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2013 - "Using a mouse model of allergic airway inflammation, we report that intranasal administration of a new selective inhibitor of GSNOR, SPL-334, caused a marked reduction in airway hyperreactivity, allergen-specific T cells and eosinophil accumulation, and mucus production in the lungs in response to allergen inhalation. "
2.	Body Weight (Weight, Body) 10/01/2015 - "Similar administration of SPL-334 for 7 days before and for an additional 14 days after BLM instillation resulted in a preventive protective effect on the BLM challenge-induced decline in total body weight and changes in total and differential BAL cellularity. " 10/01/2015 - "administration of SPL-334 alone at 0.3, 1.0, or 3.0 mg/kg had no effect on animal body weight, appearance, behavior, total and differential bronchoalveolar lavage (BAL) cell counts, or collagen accumulation in the lungs, showing no toxicity of our investigational compound. "

Related Drugs and Biologics

1.	Collagen
2.	Allergens

Related Therapies and Procedures

1.	Intranasal Administration