doliroside A

has both antigout and anti-inflammatory activities; isolated from Dolichos falcata; structure in first source

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

1.	Gouty Arthritis 10/05/2014 - "These findings indicate that doliroside A exhibits a prominent effect on ameliorating gouty arthritis induced by MSU crystals. " 10/05/2014 - "However, there is still little known about the potential beneficial effects and possible mechanism of action of doliroside A on gouty arthritis. " 10/05/2014 - "Our previous study demonstrates that Dolichos falcata Klein (DF) ameliorates the gouty arthritis induced by monosodium urate (MSU) crystals, and one of the active components, doliroside A, contributed to the anti-gouty arthritis effect of DF according to the in vitro study. " 10/05/2014 - "The action of doliroside A on gouty arthritis exerts via inhibiting the activation of caspase-1 and IL-1β secretion by affecting both LPS-induced priming and inflammasome activation." 10/05/2014 - "The results demonstrated that doliroside A (10, 20 and 40 mg/kg) ameliorated the symptoms of gouty arthritis, decreased the levels of pro-inflammatory cytokines, and inhibited the expressions of caspase-1 and pro-interleukin-1β (pro-IL-1β) proteins in MSU crystals-treated rats. "
2.	Inflammation (Inflammations) 10/05/2014 - "Doliroside A attenuates monosodium urate crystals-induced inflammation by targeting NLRP3 inflammasome."