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4- chloro- 1- (4- piperidyl)- N- (5- (2- pyridyl)- 1H- pyrazol- 4- yl)pyrazole- 3- carboxamide

inhibits myotonic dystrophy kinase-related CDC42-binding kinase (MRCK); structure in first source

Also Known As:

BDP00005290; BDP5290

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 4-chloro-1-(4-piperidyl)-N-(5-(2-pyridyl)-1H-pyrazol-4-yl)pyrazole-3-carboxamide: 3
  - Pyridines: 88
    - 4-chloro-1-(4-piperidyl)-N-(5-(2-pyridyl)-1H-pyrazol-4-yl)pyrazole-3-carboxamide: 3

Experts

1.	Belshaw, Simone: 1 article (10/2014)
2.	Bower, Justin: 1 article (10/2014)
3.	Crighton, Diane: 1 article (10/2014)
4.	Croft, Daniel R: 1 article (10/2014)
5.	Drysdale, Martin: 1 article (10/2014)
6.	McArthur, Duncan: 1 article (10/2014)
7.	McConnell, Patricia: 1 article (10/2014)
8.	Mezna, Mokdad: 1 article (10/2014)
9.	Olson, Michael F: 1 article (10/2014)
10.	Pannifer, Andrew: 1 article (10/2014)

Related Diseases

1.	Myotonic Dystrophy (Dystrophia Myotonica) 10/13/2023 - "In vitro studies of pharmacological MRCK (myotonic dystrophy kinase-related Cdc42-binding kinase) inhibitor (BDP5290) in atrial HL-1 cells were performed to evaluate PP1 holoenzyme activity on MLC2a. "
2.	Neoplasms (Cancer) 10/28/2023 - "ZDF significantly reduced the tumor volume and protein expressions of ROCK2 and MRCKβ in tumor tissues without eliciting any perceptible alterations in the physical mass of the mice, and the reduction was more pronounced than that of the BDP5290 treated group. "
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/05/2014 - "Finally, the ability of human SCC12 squamous cell carcinoma cells to invade a three-dimensional collagen matrix was strongly inhibited by 2 μM BDP5290 but not the identical concentration of Y27632, despite equivalent inhibition of MLC phosphorylation. "
4.	Breast Neoplasms (Breast Cancer) 10/05/2014 - "BDP5290 was also more effective at reducing MDA-MB-231 breast cancer cell invasion through Matrigel than Y27632. "

Related Drugs and Biologics

1.	Holoenzymes
2.	Phosphotransferases (Kinase)
3.	Proteins (Proteins, Gene)
4.	Collagen
5.	Y 27632
6.	matrigel