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tanapsin

has antineoplastic activity; isolated from Tanacetum oshanahanii; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Polycyclic Sesquiterpenes: 9
        Eudesmane Sesquiterpenes: 2
        tanapsin: 1
Polycyclic Compounds: 6
- Polycyclic Sesquiterpenes: 9
  - Eudesmane Sesquiterpenes: 2
    - tanapsin: 1

Experts

1.	Eiroa, José Luis: 1 article (03/2015)
2.	Estévez, Francisco: 1 article (03/2015)
3.	Marrero, María Teresa: 1 article (03/2015)
4.	Negrín, Gledy: 1 article (03/2015)
5.	Quintana, José: 1 article (03/2015)
6.	Rubio, Sara: 1 article (03/2015)
7.	Triana, Jorge: 1 article (03/2015)

Related Diseases

1.	Neoplasms (Cancer) 03/15/2015 - "The eudesmanolide tanapsin from Tanacetum oshanahanii and its acetate induce cell death in human tumor cells through a mechanism dependent on reactive oxygen species."
2.	Melanoma (Melanoma, Malignant) 03/15/2015 - "Tanapsin was cytotoxic against leukemia and melanoma cells, including cells that overexpress Bcl-2 and Bcl-xL, with IC50 values of approximately 10 µM, but not against quiescent or proliferating human peripheral blood mononuclear cells. " 03/15/2015 - "Tanapsin acetate was also cytotoxic against leukemia and melanoma cells and a potent apoptotic inducer. "
3.	Leukemia 03/15/2015 - "Tanapsin was cytotoxic against leukemia and melanoma cells, including cells that overexpress Bcl-2 and Bcl-xL, with IC50 values of approximately 10 µM, but not against quiescent or proliferating human peripheral blood mononuclear cells. " 03/15/2015 - "Tanapsin acetate was also cytotoxic against leukemia and melanoma cells and a potent apoptotic inducer. "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Acetates (Acetic Acid Esters)
3.	eudesmanolide