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LLY-507

inhibits methyltransferase SMYD2; structure in first source

Also Known As:

3-cyano-5-(2-(4-(2-(3-methylindol-1-yl)ethyl)piperazin-1-yl)phenyl)-N-((3-pyrrolidin-1-yl)propyl)benzamide

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Haijun: 1 article (11/2020)
2.	Liao, Liping: 1 article (11/2020)
3.	Luo, Cheng: 1 article (11/2020)
4.	Sun, Zhongya: 1 article (11/2020)
5.	Wu, Fan: 1 article (11/2020)
6.	Zhang, Bin: 1 article (11/2020)
7.	Zhang, Fengcai: 1 article (11/2020)
8.	Asada, Kayo: 1 article (01/2019)
9.	Fujii, Tomoyuki: 1 article (01/2019)
10.	Hamamoto, Ryuji: 1 article (01/2019)

Related Diseases

1.	Carcinoma (Carcinomatosis) 01/01/2019 - "Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas."
2.	Hemolysis 07/10/2023 - "Microscopic examination revealed an average grain size of 44 nm. The in vitro effect of LLY-507-IONPs, LLY-507, and IONPs was determined by MTT analysis (A549 cells) and hemolysis studies. "
3.	Neoplasms (Cancer) 05/29/2015 - "These findings suggest that LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes. " 11/15/2020 - "As a potential target for cancer therapy, there are several SMYD2 inhibitors are reported, LLY-507 as a cell-active inhibitor exhibits submicromolar potency against SMYD2 in several cancer cell lines. " 07/10/2023 - "The loss of SMYD2 due to LLY-507 suppressed tumor growth, emphysema, hemorrhage, and congestion considerably. "
4.	Hemorrhage 07/10/2023 - "The loss of SMYD2 due to LLY-507 suppressed tumor growth, emphysema, hemorrhage, and congestion considerably. "
5.	Emphysema 07/10/2023 - "The loss of SMYD2 due to LLY-507 suppressed tumor growth, emphysema, hemorrhage, and congestion considerably. "

Related Drugs and Biologics

1.	Histone Methyltransferases
2.	Poly(ADP-ribose) Polymerase Inhibitors

Related Therapies and Procedures

1.	Therapeutics