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5- (4- methylbenzamido)- 2- (phenylamino)thiazole- 4- carboxamide

an inhibitor of Traf2- and Nck-interacting kinase (TNIK); structure in first source

Also Known As:

KY-05009

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide: 2
- Sulfur Compounds: 278
  - Thiazoles: 392
    - 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide: 2

Experts

1.	Kim, Jiyeon: 2 articles (06/2017 - 01/2014)
2.	Jung, Jung-Il: 1 article (06/2017)
3.	Kim, Soon Ae: 1 article (06/2017)
4.	Lee, Yura: 1 article (06/2017)
5.	Park, Kyeong-Yong: 1 article (06/2017)
6.	Chae, Chong Hak: 1 article (01/2014)
7.	Kim, Bum Tae: 1 article (01/2014)
8.	Kim, Seong Hwan: 1 article (01/2014)
9.	Lee, Joo Yun: 1 article (01/2014)
10.	Moon, Seong-Hee: 1 article (01/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "Here, using 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide (KY-05009) with TNIK-inhibitory activity, its efficacy to inhibit EMT in cancer cells was validated. "
2.	Multiple Myeloma 06/20/2017 - "In addition, we examined the effect on TNIK of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib and whether inhibition of TNIK suppresses the interleukin-6-induced proliferation of multiple myeloma cells. " 06/20/2017 - "Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells."
3.	Adenocarcinoma of Lung 01/01/2014 - "A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells."

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