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EF25-(GSH)2

antineoplastic; structure in first source

Also Known As:

3,5-bis(2-hydroxybenzylidene)tetrahydro-4H-pyran-4-one glutathione conjugate

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Diarylheptanoids: 471
        Curcumin: 10678
        EF25-(GSH)2: 1
      - Benzene Derivatives: 17
        Phenols: 677
        Catechols: 121
        Curcumin: 10678
        EF25-(GSH)2: 1
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Heptanes: 70
        Diarylheptanoids: 471
        Curcumin: 10678
        EF25-(GSH)2: 1

Experts

1.	Bai, Yu: 1 article (01/2014)
2.	Cox, Bryan: 1 article (01/2014)
3.	Fu, Haian: 1 article (01/2014)
4.	Huang, Bei: 1 article (01/2014)
5.	Li, Yong: 1 article (01/2014)
6.	Liotta, Dennis: 1 article (01/2014)
7.	Liu, Dahai: 1 article (01/2014)
8.	Snyder, James P: 1 article (01/2014)
9.	Sun, Aiming: 1 article (01/2014)
10.	Ye, Lili: 1 article (01/2014)

Related Diseases

1.

Hepatocellular Carcinoma (Hepatoma)

01/01/2014 - "Using the MTT and colony formation assays, we determined that EF25-(GSH)2 drastically inhibits the proliferation of hepatoma cell line HepG2 with minimal cytotoxicity for the immortalized human hepatic cell line HL-7702. "
01/01/2014 - "Taken together, these data imply a fail-safe mechanism regulated by autophagy in the action of EF25-(GSH)2, suggesting the therapeutic potential of the novel curcumin analog against hepatocellular carcinoma (HCC), while offering a novel and effective combination strategy with chloroquine for the treatment of patients with HCC. "
01/01/2014 - "Here, we have assessed the therapeutic effects of a novel and water soluble curcumin analog, 3,5-bis(2-hydroxybenzylidene)tetrahydro-4H-pyran-4-one glutathione conjugate [EF25-(GSH)2], on hepatoma cells. "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Curcumin
3.	Chloroquine (Aralen)