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4- (3- chloro- 5- (1,2- dihydroxyethyl)- 2- pyridyl)- N- (5- (trifluoromethyl)- 2- pyridyl)- 3,6- dihydro- 2H- pyridine- 1- carboxamide

a TRPV1 receptor antagonist; structure in first source

Also Known As:

V116517

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - 4-(3-chloro-5-(1,2-dihydroxyethyl)-2-pyridyl)-N-(5-(trifluoromethyl)-2-pyridyl)-3,6-dihydro-2H-pyridine-1-carboxamide: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - 4-(3-chloro-5-(1,2-dihydroxyethyl)-2-pyridyl)-N-(5-(trifluoromethyl)-2-pyridyl)-3,6-dihydro-2H-pyridine-1-carboxamide: 1

Experts

1.	Arendt-Nielsen, Lars: 1 article (01/2016)
2.	Harris, Steve: 1 article (01/2016)
3.	Hummel, Michele: 1 article (01/2016)
4.	Kapil, Ram: 1 article (01/2016)
5.	Knappenberger, Terri: 1 article (01/2016)
6.	Kyle, Don: 1 article (01/2016)
7.	O'Keefe, Sarah: 1 article (01/2016)
8.	Whiteside, Garth T: 1 article (01/2016)

Related Diseases

1.	Pain (Aches) 01/01/2016 - "A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile." 01/01/2016 - "The heat pain detection and tolerance thresholds were increased significantly (P < 0.0001) by V116517. " 01/01/2016 - "This experimental, translational, experimental pain, single-center, randomized, double-blind, single-dose, 3-treatment, 3-period cross-over proof-of-concept volunteer trial studied the efficacy of a novel TRPV1 antagonist (V116517) on capsaicin- and UV-B-induced hyperalgesia. " 01/01/2016 - "Heat pain detection and tolerance thresholds showed significantly less capsaicin hyperalgesia after V116517 (P = 0.004 and P < 0.0001, respectively). "
2.	Hyperalgesia 01/01/2016 - "This experimental, translational, experimental pain, single-center, randomized, double-blind, single-dose, 3-treatment, 3-period cross-over proof-of-concept volunteer trial studied the efficacy of a novel TRPV1 antagonist (V116517) on capsaicin- and UV-B-induced hyperalgesia. " 01/01/2016 - "Heat pain detection and tolerance thresholds showed significantly less capsaicin hyperalgesia after V116517 (P = 0.004 and P < 0.0001, respectively). "
3.	Hypersensitivity (Allergy) 01/01/2016 - "In addition, the preclinical profile of V116517 in rat models of UV-B and capsaicin-induced hypersensitivity was compared with the human experimental data and overall demonstrated an alignment between 2 of the 3 end points tested. "

Related Drugs and Biologics

1.	Capsaicin (Zostrix)