N- (5- hydroxyadamantan- 2- yl)- 3- (pyridin- 2- yl)isoxazole- 4- carboxamide

has antidiabetic activity; structure in first surce

Also Known As:

HIS-388

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Adamantane: 182
        N-(5-hydroxyadamantan-2-yl)-3-(pyridin-2-yl)isoxazole-4-carboxamide: 1
    - Bridged-Ring Compounds: 1
      - Adamantane: 182
        N-(5-hydroxyadamantan-2-yl)-3-(pyridin-2-yl)isoxazole-4-carboxamide: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - N-(5-hydroxyadamantan-2-yl)-3-(pyridin-2-yl)isoxazole-4-carboxamide: 1

Experts

1.	Iwamura, Tomokatsu: 1 article (10/2014)
2.	Kainoh, Mie: 1 article (10/2014)
3.	Kawai, Koji: 1 article (10/2014)
4.	Kumagai, Hiroki: 1 article (10/2014)
5.	Nakaki, Junko: 1 article (10/2014)
6.	Nitta, Aiko: 1 article (10/2014)
7.	Okazaki, Seiji: 1 article (10/2014)
8.	Sakami, Satoshi: 1 article (10/2014)
9.	Sato, Mikiya: 1 article (10/2014)
10.	Sekiya, Yumiko: 1 article (10/2014)

Related Diseases

1.	Glucose Intolerance 10/01/2014 - "HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models." 10/01/2014 - "In nongenetic type 2 diabetic mice with disease induced by a high-fat diet and low-dose streptozotocin, HIS-388 also significantly decreased postprandial blood glucose and plasma insulin levels and improved glucose intolerance. "
2.	Obesity 10/01/2014 - "HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models."
3.	Insulin Resistance 10/01/2014 - "Moreover, amelioration of diabetic symptoms by HIS-388 was at least in part attributable to an antiobesity effect or improvement of hepatic insulin resistance. " 10/01/2014 - "In diet-induced obese mice, HIS-388 significantly decreased fasting blood glucose, plasma insulin concentration, and homeostasis model assessment-insulin resistance score, and ameliorated insulin sensitivity. " 10/01/2014 - "HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models."
4.	Hyperinsulinism (Hyperinsulinemia) 10/01/2014 - "In cortisone pellet-implanted mice in which hypercortisolism and hyperinsulinemia occur, single administration of HIS-388 exhibited potent and prolonged suppression of plasma cortisol and lowered plasma insulin levels. "
5.	Type 2 Diabetes Mellitus (MODY) 10/01/2014 - "Our results suggest that HIS-388 is a potent agent against type 2 diabetes. "

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Oxidoreductases (Dehydrogenase)
3.	Insulin (Novolin)
4.	Blood Glucose (Blood Sugar)
5.	Pyruvic Acid (Pyruvate)
6.	Hydrocortisone (Cortisol)
7.	Cortisone