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GSK2194069

a beta-ketoacyl reductase inhibitor; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - GSK2194069: 4
  - Pyrrolidines: 115
    - GSK2194069: 4

Experts

1.	Hopf, Carsten: 1 article (01/2021)
2.	Levkin, Pavel A: 1 article (01/2021)
3.	Paulssen, Dorothea: 1 article (01/2021)
4.	Popova, Anna A: 1 article (01/2021)
5.	RamalloGuevara, Carina: 1 article (01/2021)
6.	Jung, Byung Hwa: 1 article (11/2020)
7.	Kang, Soosung: 1 article (11/2020)
8.	Lee, Hyunbeom: 1 article (11/2020)
9.	Oh, Ju Eun: 1 article (11/2020)
10.	Park, Jinyoung: 1 article (11/2020)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 11/10/2020 - "Therefore, to confirm the metabolic alterations at the cellular level during FAS inhibition, we treated LNCaP-LN3 prostate cancer cells with FAS inhibitors (Fasnall, GSK2194069, and TVB-3166). " 04/07/2020 - "The identified compounds were tested for their inhibitor potencies in vitro using a substrate-based activity assay monitoring FASN-dependent NADPH consumption in LNCaP prostate cancer cell preparation, in parallel with selected reference inhibitors, including orlistat (THL), GSK2194069, GSK837149A, platensimycin and BI-99179. "
2.	Neoplasms (Cancer) 09/01/2014 - "We describe here the identification of GSK2194069, a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS; the characterization of its enzymatic and cellular mechanism of action; and its inhibition of human tumor cell growth. "
3.	Lung Neoplasms (Lung Cancer) 01/01/2021 - "Using A549 lung cancer cells, concentration-response profiling of a pharmaceutical compound, the fatty acid synthase inhibitor GSK2194069, are demonstrated. "

Related Drugs and Biologics

1.	Fatty Acid Synthases (Fatty Acid Synthase)
2.	Oxidoreductases (Dehydrogenase)
3.	NADP (NADPH)
4.	Orlistat (Xenical)
5.	GSK837149A
6.	platensimycin
7.	4- (1- (5- (3,4- dimethyl- 1H- pyrazol- 5- yl)- 2,4- dimethylbenzoyl)azetidin- 3- yl)benzonitrile