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gardenin B

has antineoplastic activity; structure in first source

Also Known As:

5-demethyltangeretin

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        gardenin B: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        gardenin B: 5

Experts

1.	Ho, Chi-Tang: 3 articles (04/2020 - 08/2013)
2.	Li, Shiming: 2 articles (04/2020 - 12/2013)
3.	Pan, Min-Hsiung: 2 articles (04/2020 - 08/2013)
4.	Xiao, Hang: 2 articles (01/2020 - 12/2013)
5.	Zheng, Jinkai: 2 articles (01/2020 - 12/2013)
6.	Chou, Ya-Chun: 1 article (04/2020)
7.	Gao, Zili: 1 article (01/2020)
8.	Li, Fang: 1 article (01/2020)
9.	Li, Zhengze: 1 article (01/2020)
10.	Sun, Yue: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 04/15/2020 - "Preparation and evaluation of self-microemulsifying delivery system containing 5-demethyltangeretin on inhibiting xenograft tumor growth in mice." 01/01/2020 - "5-Demethyltangeretin (5DT) is a unique polymethoxyflavone mainly found in the peel of citrus, and has shown potent suppressive effects on multiple human cancer cells. " 08/28/2013 - "The presence of a methyl donor potentially caused the transformation of 5-demethyltangeretin and reduced its anti-cancer-cell-proliferation activities. " 04/15/2020 - "5-Demethyltangeretin (5-DTAN), a polymethoxylated flavone found in citrus peels, exhibits highly potent anti-cancer activity. "
2.	Leukemia 08/25/2016 - "Here we investigated the antiproliferative activity of the flavonoids isolated from Baccharis scandens against human leukemia cell lines and found that the methoxyflavonoid gardenin B was the most cytotoxic compound against HL-60 and U-937 cells, showing IC50 values between 1.6 and 3.0 μM, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. " 08/25/2016 - "Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species."
3.	Colonic Neoplasms (Colon Cancer) 01/01/2020 - "Identification of Xanthomicrol as a Major Metabolite of 5-Demethyltangeretin in Mouse Gastrointestinal Tract and Its Inhibitory Effects on Colon Cancer Cells."
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/01/2013 - "5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis."

Related Drugs and Biologics

1.	Caspases
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Flavonoids
4.	xanthomicrol
5.	flavone