N- (2- (diethylamino)ethyl)- 5- fluoropicolinamide

01/01/2023 - "In this study, we sought to investigate the value of 18F-5-FPN in assessing the response to photothermal therapy (PTT) in melanoma via comparison with 18F-fluorodeoxyglucose (18F-FDG) to reveal an early response, recognize early recurrence, and distinguish the inflammatory response during the treatment. "
07/01/2017 - "18F-5-fluoro-N-(2-(Diethylamino)ethyl)picolinamide (18F-5-FPN) is a new positron-emission tomography (PET) radiopharmaceutical with potential for the detection of lymph node (LN) and pulmonary metastatic lesions of melanoma. "
11/06/2017 - "The aim in this research was to optimize the structure of 18F-5-FPN with triethylene glycol to reduce liver uptake as well as improve pharmacokinetics, and to evaluate its performance in detection of melanoma liver and lung metastases. "
07/01/2017 - "Detection of melanoma metastases with PET-Comparison of 18F-5-FPN with 18F-FDG."
01/01/2023 - "Compared with 18F-FDG, 18F-5-FPN PET could estimate PTT efficacy in melanoma, monitor minimal recurrence, and distinguish melanoma from inflammation and other carcinoma types, thanks to its high affinity to melanin. "

11/06/2017 - "More importantly, 18F-PEG3-FPN uptake by liver (2.27 ± 0.45 and 1.74 ± 0.35% ID/g, at 1 and 2 h) was significantly lower than that of 18F-5-FPN, and the lesions in lung and liver could be clearly detected by 18F-PEG3-FPN PET imaging in mouse models of pulmonary or hepatic metastases. "
07/01/2017 - "The related uptakes of 18F-5-FPN and 18F-FDG were 3.12±1.17% ID/g and 1.48±0.15% ID/g, respectively (n=5, P<0.05), with lung metastasis-to-muscle ratios of 8.16±3.12 and 1.28±0.18 (n=5, P<0.01), respectively. "
07/01/2017 - "LN metastases with a diameter<1cm were more visible on 18F-5-FPN PET imaging than 18F-FDG imaging. "
11/06/2017 - "The aim in this research was to optimize the structure of 18F-5-FPN with triethylene glycol to reduce liver uptake as well as improve pharmacokinetics, and to evaluate its performance in detection of melanoma liver and lung metastases. "
07/01/2017 - "Detection of melanoma metastases with PET-Comparison of 18F-5-FPN with 18F-FDG."

07/01/2014 - "To evaluate the performance of N-[2-(diethylamino)ethyl]-(18)F-5-fluoropicolinamide ((18)F-P3BZA) for visualizing porcine retinal pigment epithelium (pRPE) cells transplanted in the striatum for the treatment of Parkinson disease and to monitor the long-term activity of implanted pRPE cells by means of (18)F-P3BZA positron emission tomography (PET)/computed tomography (CT) in vivo. "

01/01/2023 - "The mean tumor uptakes of 18F-5-FPN on day 2 (7.52 ± 3.65 %ID/g) and day 6 (10.22 ± 6.00 %ID/g) were much lower than that before treatment (18.33 ± 4.98 %ID/g, p < 0.01). "

01/01/2023 - "Compared with 18F-FDG, 18F-5-FPN PET could estimate PTT efficacy in melanoma, monitor minimal recurrence, and distinguish melanoma from inflammation and other carcinoma types, thanks to its high affinity to melanin. "