LL202 flavonoid

01/01/2019 - "LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO-1 pathway."
01/01/2019 - "In vivo, we validated the role of LL202 in dextran sulfate sodium- and TNBS-induced colitis models, respectively. "
09/27/2016 - "Mechanically, LL202 could decrease the expression and nuclear translation of AP-1 to protect against DSS-induced colitis. "
09/27/2016 - "LL202 protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting MAPK/AP-1 signaling."
09/27/2016 - "In this study, we investigated the anti-inflammatory effect of LL202 on intestinal inflammation by establishing dextran sulfate sodium (DSS)-induced experimental colitis. "

09/27/2016 - "In conclusion, our study demonstrated that LL202 could exert its anti-inflammatory effect via inhibiting MAPK/AP-1 signaling, which suggested that LL202 might be a potential effective drug for the treatment of inflammatory bowel diseases."

07/03/2014 - "Finally, in vivo studies, LL-202 significantly suppressed the growth of MCF-7 breast cancer xenograft tumors in a dose-dependent manner with low systemic toxicity. "
07/03/2014 - "LL-202, a newly synthesized flavonoid, inhibits tumor growth via inducing G(2)/M phase arrest and cell apoptosis in MCF-7 human breast cancer cells in vitro and in vivo."

09/27/2016 - "However, the exact role of LL202 in inflammation along with its mechanism has not been explored. "
09/27/2016 - "In this study, we investigated the anti-inflammatory effect of LL202 on intestinal inflammation by establishing dextran sulfate sodium (DSS)-induced experimental colitis. "

07/03/2014 - "In this study, we demonstrated that LL-202 inhibited the growth and proliferation of human breast cancer MCF-7 cells in a concentration and time-dependent manner. "
07/03/2014 - "Finally, in vivo studies, LL-202 significantly suppressed the growth of MCF-7 breast cancer xenograft tumors in a dose-dependent manner with low systemic toxicity. "
07/03/2014 - "In conclusion, the results showed that LL-202 had significant anticancer effects against human breast cells via the induction of apoptosis and G2/M phase arrest and it may be a novel anticancer agent for treatment of breast cancer. "
07/03/2014 - "LL-202, a newly synthesized flavonoid, inhibits tumor growth via inducing G(2)/M phase arrest and cell apoptosis in MCF-7 human breast cancer cells in vitro and in vivo."