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curcusone D

a ubiquitin-proteasome pathway inhibitor from Jatropha, structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - curcusone D: 2

Experts

1.	Abegg, Daniel: 1 article (01/2021)
2.	Adibekian, Alexander: 1 article (01/2021)
3.	Cai, Zhong-Jian: 1 article (01/2021)
4.	Cui, Chengsen: 1 article (01/2021)
5.	Dai, Mingji: 1 article (01/2021)
6.	Dwyer, Brendan G: 1 article (01/2021)
7.	Hoch, Dominic G: 1 article (01/2021)
8.	Liu, Chang: 1 article (01/2021)
9.	Liu, Jie-Qing: 1 article (01/2021)
10.	Qiu, Nan: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "We further demonstrate for the first time that BRAT1 can be inhibited by curcusone D, resulting in impaired DNA damage response, reduced cancer cell migration, potentiated activity of the DNA damaging drug etoposide, and other phenotypes similar to BRAT1 knockdown."
2.	Multiple Myeloma 06/01/2014 - "Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth."

Related Drugs and Biologics

1.	Proteasome Endopeptidase Complex (Proteasome)
2.	Ubiquitin
3.	Etoposide (VP 16)
4.	DNA (Deoxyribonucleic Acid)
5.	Bortezomib (Velcade)