deoxyaminopteroic acid

carboxypeptidase cleavage product of methotrexate (minus glutamic acid); RN given refers to parent cpd; structure

Also Known As:

2,4-diamino-N(10)-methylpteroic acid; 2,4-diamino-N10-methylpteroic acid; 4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoic acid; 4-amino-4-deoxy-N 10-methylpteroic acid; 4-amino-4-deoxy-N-10-methylpteroic acid; 4-amino-4-deoxy-N-10-methylpteroic acid hydrochloride (2:1); 4-deoxy-4-amino-N(10)-methylpteroic acid; N-10-methyl-4-deoxy-4-aminopteroate

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Aminopterin: 248
        Methotrexate: 24010
        deoxyaminopteroic acid: 2

Experts

1.	Barceló, Bernardino: 1 article (12/2018)
2.	Berga, Francisco: 1 article (12/2018)
3.	Costa-Bauza, Antonia: 1 article (12/2018)
4.	Elorza, Miguel Ángel: 1 article (12/2018)
5.	Gimenez, Sandra: 1 article (12/2018)
6.	Gomila, Isabel: 1 article (12/2018)
7.	Grases, Félix: 1 article (12/2018)
8.	Luna, Pablo: 1 article (12/2018)
9.	Martorell, Clara: 1 article (12/2018)
10.	Rey, Juan: 1 article (12/2018)

Related Diseases

1.	Brain Neoplasms (Brain Tumor) 01/01/2016 - "A rapid and robust method for measuring methotrexate (MTX) and its two primary metabolites, 7-hydroxymethotrexate (7-OHMTX) and 2,4-diamino-N10-methylpteroic acid (DAMPA), was developed for use in pharmacokinetic studies of plasma and cerebrospinal fluid samples collected from infants with malignant brain tumors. "
2.	Osteosarcoma (Osteogenic Sarcoma) 12/01/2018 - "2,4-Diamino-N10-methylpteroic acid (DAMPA) crystalluria in a patient with osteosarcoma treated with carboxypeptidase-G2 rescue after high-dose methotrexate-induced nephrotoxicity."
3.	Crystalluria 12/01/2018 - "2,4-Diamino-N10-methylpteroic acid (DAMPA) crystalluria in a patient with osteosarcoma treated with carboxypeptidase-G2 rescue after high-dose methotrexate-induced nephrotoxicity."

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	7-hydroxymethotrexate