Levonorgestrel (Plan B)

A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.

Also Known As:

Networked: 1969 relevant articles (230 outcomes, 420 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Bahamondes, Luis: 35 articles (02/2024 - 01/2002)
2.	Seong, Seok Ju: 14 articles (03/2019 - 06/2010)
3.	Hurskainen, Ritva: 14 articles (11/2016 - 01/2003)
4.	Paavonen, Jorma: 13 articles (11/2016 - 01/2003)
5.	Monteiro, Ilza: 12 articles (06/2023 - 05/2002)
6.	Curtis, Kathryn M: 12 articles (04/2020 - 06/2002)
7.	Bongers, Marlies Y: 11 articles (01/2024 - 03/2004)
8.	Lukkari-Lax, Eeva: 11 articles (01/2023 - 04/2009)
9.	Kim, Mi Kyoung: 11 articles (03/2019 - 06/2010)
10.	Jensen, Jeffrey T: 10 articles (01/2023 - 01/2003)

Related Diseases

1.	Menorrhagia 01/01/2020 - "Most women who self-report heavy menstrual bleeding experience significant improvement quickly after levonorgestrel 52-mg intrauterine system insertion. " 11/01/2016 - "The levonorgestrel-releasing intrauterine system is considered a highly effective treatment of heavy menstrual bleeding (HMB). " 06/01/2001 - "The FibroPlant levonorgestrel IUS is effective in significantly reducing the amount of menstrual blood loss in women with menorrhagia. " 01/01/2013 - "The aim of the present study was to identify variables associated with treatment failure in women with menorrhagia who were treated with thermal balloon ablation (TBA) or levonorgestrel releasing intrauterine system (LNG-IUS), and to determine if there are subgroups where one treatment type is more effective than the other. " 01/01/2012 - "The levonorgestrel-releasing intrauterine system is an effective treatment for menorrhagia. "
2.	Hemorrhage 12/01/2000 - "The FibroPlant levonorgestrel intrauterine system is also highly efficacious in controlling bleeding in women presenting with excessive menstrual flow. " 08/01/2000 - "Norplant users with BTB problems also had a non-significant reduction in level 2 vessels compared to women without bleeding problems (4 +/- 2 versus 11 +/- 4%, P = 0.0667). " 03/01/1995 - "In Norplant-II implants users, 75 to 80% of women had irregularities in bleeding pattern during the first year of use which improved with prolonged use. " 02/01/2023 - "Real-world evidence from the Kyleena® Satisfaction Study in routine clinical practice shows high bleeding profile satisfaction with levonorgestrel 19.5 mg IUD regardless of age or parity. " 12/01/2022 - "The aim of this study was to evaluate the satisfaction and menstrual bleeding pattern with levonorgestrel-releasing intrauterine systems (LNG-IUD) in young women. "
3.	Endometrial Hyperplasia 09/01/2008 - "The levonorgestrel-releasing intrauterine system seems to be an effective and safe alternative in the treatment of peri- and postmenopausal women with (simple) endometrial hyperplasia without atypia." 05/01/2016 - "The aim of the study was to evaluate the efficacy of the levonorgestrel intrauterine system (LNG-IUS) for treatment of endometrial hyperplasia (EH). " 06/01/2015 - "Efficacy of the Levonorgestrel-Releasing Intrauterine System on IVF-ET Outcomes in PCOS With Simple Endometrial Hyperplasia." 05/01/2016 - "Management of Endometrial Hyperplasia With a Levonorgestrel-Releasing Intrauterine System: A Korean Gynecologic-Oncology Group Study." 11/01/2012 - "Observational studies suggested that levonorgestrel-releasing intrauterine system (LNG-IUS) has been successfully used to treat endometrial hyperplasia without cytological atypia and selected cases of atypical endometrial hyperplasia. "
4.	Endometriosis 09/01/2018 - "After surgery for endometriosis, a CHC or 52mg levonorgestrel-releasing IUS is recommended as first-line treatment when pregnancy is not desired. " 01/01/2017 - "The objective of the study was to evaluate whether a maintenance levonorgestrel-releasing intrauterine system is effective for preventing postoperative endometrioma recurrence. " 01/01/2022 - "To explore the therapeutic efficacy of the levonorgestrel-releasing intrauterine system combined with turtle shell decocted pills for endometriosis and their effect on cellular immune function. " 09/01/2018 - "Comparison of the efficacy of diegnogest and levonorgestrel-releasing intrauterine system after laparoscopic surgery for endometriosis." 07/01/2011 - "The levonorgestrel (LNG) intrauterine system (LNG-IUS) has been shown to improve symptoms in women with minimal to moderate endometriosis. "
5.	Adenomyosis 01/01/2023 - "In conclusions, the use of high-intensity focused ultrasound combined with the levonorgestrel-releasing intrauterine system for the treatment of adenomyosis is safe and effective even though the long-term effect remains to be confirmed." 01/01/2024 - "Laparoscopic adenomyomectomy combined with levonorgestrel-releasing intrauterine system is effective for long-term management of adenomyosis." 02/01/2018 - "To evaluate whether a maintenance levonorgestrel-releasing intrauterine system is effective for preventing the recurrence of postoperative adenomyosis-related symptoms. " 12/01/2015 - "The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective for the medical treatment of adenomyosis. " 01/01/2019 - "Mirena is effective and safe in the long term management of adenomyosis, but about one third patients may require further treatment because of the expulsion or ineffectiveness of Mirena."

Related Drugs and Biologics

1.	Levonorgestrel (Plan B)
2.	Progestins (Progestagens)
3.	Gonadotropin-Releasing Hormone (GnRH)
4.	Oral Contraceptives
5.	Ethinyl Estradiol (Estinyl)
6.	Contraceptive Agents (Contraceptives)
7.	dienogest
8.	Medroxyprogesterone Acetate (Depo-Provera)
9.	Mifepristone (RU 486)
10.	Cyproterone Acetate

Related Therapies and Procedures

1.	Intrauterine Devices (Intrauterine Device)
2.	Contraception (Birth Control)
3.	Therapeutics
4.	Hysterectomy
5.	Endometrial Ablation Techniques