Albendazole (Albenza)

A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)

Also Known As:

Albenza; Albendazole Monohydrochloride; Albendoral; Andazol; Bendapar; Bilutac; Digezanol; Disthelm; Endoplus; Eskazole; Gascop; Lurdex; Mediamix V Disthelm; Metiazol; SK&F-62979; SKF-62979; Valbazen; Zentel; Monohydrochloride, Albendazole; SK&F 62979; SK&F62979; SKF 62979; SKF62979; Carbamic acid, (5-(propylthio)-1H-benzimidazol-2-yl)-, methyl ester

Networked: 2587 relevant articles (475 outcomes, 390 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Weil, Gary J: 40 articles (01/2023 - 02/2004)
2.	Keiser, Jennifer: 38 articles (03/2024 - 04/2008)
3.	Utzinger, Jürg: 24 articles (01/2022 - 04/2005)
4.	Hattendorf, Jan: 19 articles (03/2024 - 12/2010)
5.	King, Christopher L: 18 articles (01/2023 - 01/2008)
6.	Hoerauf, Achim: 15 articles (01/2024 - 04/2006)
7.	Albonico, Marco: 15 articles (01/2022 - 05/2003)
8.	Jung-Cook, Helgi: 14 articles (07/2023 - 03/2006)
9.	Ali, Said M: 14 articles (03/2023 - 01/2012)
10.	Horton, John: 14 articles (01/2020 - 12/2002)

Related Diseases

1.	Infections 06/28/2018 - "Albendazole was found to be highly efficacious against Ascaris spp., with a cure rate of 91.4% (95% CI: 85.9-95.2%) and infection intensity reduction rate of 95.6% (95% CI: 88.3-100%). " 05/01/2008 - "Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees." 02/01/1996 - "The postmortem finding of complete clearance of microsporidia from body tissues is significant for future albendazole treatment of patients infected with E intestinalis and provides strong support for the value of the autopsy in evaluating the therapeutic efficacy of antimicrobials in emerging infections." 03/01/1989 - "Albendazole proved very effective and safe in the treatment of single and multiple helminth infections in children under 2 years of age, achieving cure rates of 100% in both Ascaris lumbricoides and Necator americanus respectively, 83% in Trichuris trichiura and 66% in Hymenolepis nana. " 12/01/2023 - "Although no impact was seen on overall prevalence, community-wide MDA was more effective in lowering N. americanus infection intensity in schoolchildren compared to school-based targeted PC, measured 12 months after one round of albendazole deworming with high coverage. "
2.	Echinococcosis (Hydatid Cysts) 01/07/2015 - "Radical surgery with pre- and post-operative administration of albendazole is the best treatment option for liver hydatid cysts due to low recurrence and complication rates." 10/01/2006 - "We think that albendazole in the treatment of the hydatid disease is very effective in condition to give a continuous treatment for a long time. " 09/01/1992 - "We report a 33-year-old woman who was harboring multiple cerebral hydatid cysts and who was treated successfully with albendazole. " 12/01/2019 - "Allium Sativum Methanolic Extract (garlic) Improves Therapeutic Efficacy of Albendazole Against Hydatid Cyst: In Vivo Study." 09/01/1996 - "Albendazole in this study has proved to be effective in decreasing the viability of liver hydatid cysts when given for 3 weeks preoperatively."
3.	Cysts 01/01/2023 - "Currently, the best treatment approach is complete surgical removal of the cyst, irrigation with a scolicidal agent, and postoperative follow-up with a long-term course of albendazole. " 01/01/2001 - "Albendazole, the drug most often used, appears to have the greatest efficacy of any agent used so far; nevertheless, apparent cure (shrinkage or disappearance of cysts) ranges only between 20% and 30% of cases. " 01/01/2021 - "Regarding radiological outcomes, albendazole probably slightly improves the complete radiological clearance of lesions (RR 1.22, 95% CI 1.07 to 1.39; 13 trials, 1324 participants; moderate-certainty evidence) and the evolution of cysts (RR 1.27, 95% CI 1.10 to 1.47; 6 trials, 434 participants; moderate-certainty evidence). " 04/01/2023 - "The condition was treated successfully with albendazole, but the patient requested the cyst removed. " 11/01/2021 - "Compared with the untreated control (13.1 ± 2.2 g), there was a significant reduction in cysts wet weight in rAd-mIL-28B group (8.3 ± 3.5 g) (P < 0.05), especially in Albendazole (ABZ) + rAd-mIL-28B group (5.8 ± 1.4 g) (P < 0.01). "
4.	Neurocysticercosis 11/01/1989 - "We conclude that albendazole administered according to the 3-day therapeutic scheme proposed above is as highly effective for the treatment of parenchymal brain cysticercosis as the 30-day scheme." 10/01/1988 - "Our results indicated that a short course of albendazole is highly effective for treatment of neurocysticercosis." 04/01/1987 - "We conclude that albendazole is highly effective for the treatment of parenchymal brain cysticercosis. " 08/01/2002 - "Albendazole (ABZ) is effective in the treatment of neurocysticercosis. " 11/01/1995 - "Reports from Mexico suggest that albendazole is effective in the treatment of neurocysticercosis. "
5.	Giardiasis 10/06/2023 - "Moreover, our in vivo murine model of giardiasis displayed a strong correlation, supporting the efficacy of RetroABZ, which exhibited an eleven-fold increase in potency compared to albendazole, with median effective dose (ED50) values of 5 µg/kg and 55 µg/kg, respectively. " 04/15/2004 - "Albendazole is as effective as metranidazole in adults' giardiasis. " 05/02/1996 - " Albendazole was effective against giardiasis in children in Bangladesh but ineffective in adult travelers returning from tropical areas. " 09/01/2006 - "Albendazole is an easy, safe and effective treatment for giardiasis." 06/01/2004 - "The efficacy of albendazole for the treatment of giardiasis has been indicated by previous in-vitro and in-vivo studies. "

Related Drugs and Biologics

1.	Praziquantel (Biltricide)
2.	Mebendazole (Anti-Worm)
3.	Ivermectin (Mectizan)
4.	Diethylcarbamazine (Hetrazan)
5.	benzimidazole
6.	Anthelmintics
7.	Metronidazole (Metric)
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	Steroids
10.	Antiparasitic Agents (Antiparasitics)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Mass Drug Administration
5.	Microspheres (Microsphere)