Riboflavin (Vitamin B2)

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.

Also Known As:

Networked: 2265 relevant articles (179 outcomes, 318 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hafezi, Farhad: 22 articles (01/2023 - 10/2006)
2.	McNulty, Helene: 21 articles (01/2023 - 10/2002)
3.	Ward, Mary: 20 articles (01/2023 - 01/2006)
4.	Mazzotta, Cosimo: 13 articles (08/2022 - 05/2006)
5.	Strain, J J: 12 articles (12/2022 - 01/2006)
6.	Wollensak, Gregor: 12 articles (09/2019 - 05/2003)
7.	Spoerl, Eberhard: 11 articles (01/2023 - 05/2003)
8.	Kymionis, George D: 11 articles (01/2016 - 11/2007)
9.	Naseem, Imrana: 10 articles (12/2019 - 03/2002)
10.	Seiler, Theo: 10 articles (10/2015 - 05/2003)

Related Diseases

1.	Keratoconus 03/01/2012 - "The study demonstrated significant and rapid functional improvement in pediatric patients younger than 18 years with progressive keratoconus, undergoing riboflavin-UVA–induced cross-linking. " 01/01/2017 - "I-CXL using 0.1% riboflavin halts keratoconus progression within 24mo, resulting in a significant improvement in visual and topographic parameters. " 03/11/2019 - "Retention ring-assisted continuous application of riboflavin for 10 minutes in pulsed-light accelerated cross-linking is a comparably safe and effective treatment for halting the progression of keratoconus in 12 months when compared to outcomes of the standard Dresden protocol shown in previous reports." 05/01/2013 - "CXL with riboflavin and UV-A improved CS and inhibited the progression of keratoconus. " 03/01/2023 - "The objective of this study was to compare the effectiveness and safety of short versus standard riboflavin induction times in cross-linking (CXL) for keratoconus. "
2.	Migraine Disorders (Migraine) 02/01/1998 - "We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. " 05/01/2014 - "RCT studies in adult confirmed that riboflavin is safe and probably effective in migraine prophylaxis, based on level B evidence. " 08/01/2020 - "Low-dose riboflavin is safe and modestly effective for migraines in children. " 03/01/2014 - "Is riboflavin, an alternative to traditional pharmacologic agents, effective and safe for prevention of migraine in children? " 11/01/2008 - "This is the first study to evaluate the efficacy of riboflavin for migraine prophylaxis in children. "
3.	Keratitis 01/01/2016 - "PACK-CXL appears as a promising treatment option for difficult-to-treat cases of fungal keratitis and 0.25% riboflavin concentration increases fungicidal effect of the procedure dramatically." 12/11/2018 - "[Therapeutic efficacy of ultraviolet combined with riboflavin for the rabbit bacterial keratitis]." 08/01/2008 - "Riboflavin/UVA was effective against SA, SE, PA, MRSA, MDRPA, and DRSP, but was ineffective on CA and has the potential for use in treatment of microbial keratitis in the future." 08/01/2008 - "Antimicrobial efficacy of riboflavin/UVA combination (365 nm) in vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis." 02/01/2010 - "To evaluate the antibacterial efficacy of photo-activated riboflavin using Ultraviolet A (UVA) on three bacterial strains commonly detected in keratitis. "
4.	Multiple Acyl Coenzyme A Dehydrogenase Deficiency 09/01/2017 - "Both patients were diagnosed with glutaric aciduria type II. Their symptoms were improved after high-dose vitamin B2 treatment. " 01/01/2023 - "Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi002-A) from a patient with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency." 12/01/2022 - "Furthermore, 8 of 15 patients with the later-onset form of ETFDH deficiency treated with riboflavin were riboflavin non-responders. " 12/01/2022 - "The causes of MADD were ETFDH deficiency in 26 patients, ETFA deficiency in four, ETFB deficiency in six, and riboflavin metabolism disorder in one. " 01/01/2022 - "To evaluate the clinical, pathological, and genetic features of patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (RR-MADD). "
5.	Muscle Weakness 01/01/2021 - "Exercise intolerance and muscle weakness were dramatically improved in all patients treated with riboflavin (100 mg) daily following diagnosis. " 12/02/2020 - "Riboflavin treatment dramatically improved muscle weakness. " 12/26/2018 - "Muscle weakness was quickly improved by riboflavin supplementation, but sensory disturbances required a long-term treatment. " 01/01/2022 - "Among 48 MADD patients with a follow-up of 6.1 years on average, 31 patients were free of muscle weakness recurrence, while 17 patients had episodes of slight muscle weakness upon riboflavin withdrawal, but recovered after retaking a small-dose of riboflavin for a short-term. " 01/01/2022 - "We showed that fluctuating proximal muscle weakness, exercise intolerance and dramatic responsiveness to riboflavin treatment were essential clinical features for all 110 MADD patients. "

Related Drugs and Biologics

1.	Collagen
2.	coenzyme Q10 (CoQ10)
3.	Magnesium
4.	Ascorbic Acid (Vitamin C)
5.	Vitamins
6.	Carnitine (L-Carnitine)
7.	Riboflavin (Vitamin B2)
8.	Niacin (Nicotinic Acid)
9.	Vitamin A (Retinol)
10.	Solutions

Related Therapies and Procedures

1.	Corneal Cross-Linking
2.	Therapeutics
3.	Photorefractive Keratectomy
4.	Lasers (Laser)
5.	Aftercare (After-Treatment)