Nitrofurantoin (Macrodantin)

A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.

Also Known As:

Networked: 1179 relevant articles (73 outcomes, 94 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Harbarth, Stephan: 8 articles (11/2023 - 10/2013)
2.	Mouton, Johan W: 8 articles (09/2019 - 09/2015)
3.	Huttner, Angela: 6 articles (11/2023 - 09/2015)
4.	Muller, Anouk E: 6 articles (02/2022 - 09/2015)
5.	Hooton, Thomas M: 5 articles (02/2024 - 06/2003)
6.	Wijma, Rixt A: 5 articles (01/2020 - 11/2018)
7.	Koren, Gideon: 5 articles (02/2015 - 02/2007)
8.	Stewardson, Andrew J: 4 articles (02/2024 - 01/2019)
9.	Godycki-Cwirko, Maciek: 4 articles (11/2023 - 12/2014)
10.	Leibovici, Leonard: 4 articles (11/2023 - 05/2017)

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection) 10/01/2010 - "Nitrofurantoin shows good efficacy against most bacteria expected in urinary tract infection, and the development of resistance is low. " 11/06/2023 - "Three days of nitrofurantoin at 100 mg twice daily is recommended as first-line treatment for uncomplicated urinary tract infection (UTI) in evidence-based guidelines across the UK. " 01/01/2020 - "International guidelines have recommended the long-acting formulation of nitrofurantoin as first-line treatment for uncomplicated urinary tract infections (UTIs) since 2010. " 10/12/2012 - "Nitrofurantoin has been in use since 1953 as an effective agent for the prevention of recurrent urinary tract infection. " 01/01/2001 - "We conclude that nitrofurantoin may provide effective treatment of urinary tract infections caused by vancomycin-resistant enterococci."
2.	Cystitis 12/20/2022 - "The data presented in this study combined with in vitro sensitivity data from common urine pathogens and the lack of observed adverse effects suggest that nitrofurantoin in a standard dosing regimen could be effective in sporadic bacterial cystitis treatment in dogs. " 11/01/2019 - "It is unknown whether nitrofurantoin 50 mg normal-release every 6 h (NF50) and nitrofurantoin 100 mg extended-release every 12 h (NF100) are equally effective for treating cystitis in primary care. " 11/12/2007 - "There is a paucity of data on the efficacy of nitrofurantoin for the treatment of acute uncomplicated cystitis in regimens shorter than 7 days. " 09/01/2021 - "The purpose of this study was to compare the efficacy and safety of nitrofurantoin for the treatment of cystitis in males and females with variable degrees of renal dysfunction. " 06/01/2020 - "Therefore, the objectives of this study were to evaluate the appropriateness of empiric FQ use compared to nitrofurantoin for uncomplicated cystitis and to determine whether there are any trends or predictors of empiric FQ versus nitrofurantoin use for uncomplicated cystitis. "
3.	Infections 03/09/2022 - "Therapeutic Efficacy of Orally Administered Nitrofurantoin against Animal African Trypanosomosis Caused by Trypanosoma congolense Infection." 10/01/2000 - "The regimen with nitrofurantoin failed to eradicate infection from any of the six SS1-infected mice (P < or =0.001) and cleared infection from one of seven mice inoculated with the rdxA mutant. " 01/01/2022 - "This multinational study aimed to investigate the association between prenatal nitrofurantoin exposure and childhood leukaemia while accounting for maternal infection. " 07/14/1956 - "[Treatment of urinary infections with furadantin; continued study]." 08/21/1954 - "Nitrofurantoin: a study in vitro and in vivo in one hundred cases of urinary infection."
4.	Bacteriuria 02/01/2009 - "To evaluate whether a 1-day nitrofurantoin regimen is as effective as a 7-day regimen in eradicating asymptomatic bacteriuria during pregnancy. " 05/01/1999 - "Bacteriuria after combined urodynamics and cystourethroscopy was not improved by a 1-day course of nitrofurantoin." 05/01/1999 - "To determine the efficacy of prophylactic nitrofurantoin in preventing bacteriuria after urodynamics and cystourethroscopy. " 06/01/1989 - "Subsequent bacteriuria with Gram-positive cocci was eliminated by nitrofurantoin (50 mg qid) within four days. " 09/01/1975 - "A short course of nitrofurantoin eliminated the bacteriuria in 93% of the girls in the treatment group. "
5.	Pyelonephritis 03/01/1972 - "Improved treatment of chronic pyelonephritis with nitrofurantoin in combination with deglycyrrhizinated liquorice." 03/01/1982 - "[Studies on the kinetics of nitrofurantoin (Nifurantin) in normal pregnancy, gestoses, pyelonephritis and labor (author's transl)]." 04/01/2018 - "In the pyelonephritis group, trimethoprim resistance in urinary isolates was 16/47 (34.0%) compared with 3/47 (6.4%) for nitrofurantoin. " 01/01/1969 - "A comparison of the antibacterial effect of nitrofurantoin and two nitrofuran compounds on experimental Escherichia coli pyelonephritis." 01/01/1964 - "LONG-TERM FOLLOW-UP ON THE NITROFURANTOIN TREATMENT OF PATIENTS WITH CHRONIC PYELONEPHRITIS."

Related Drugs and Biologics

1.	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Fosfomycin
4.	Ciprofloxacin (Cipro)
5.	Trimethoprim (Proloprim)
6.	Ampicillin (Omnipen)
7.	Nitrofurantoin (Macrodantin)
8.	Thymidine Monophosphate (TMP)
9.	bismuth subsalicylate (Pepto-bismol)
10.	Norfloxacin

Related Therapies and Procedures

1.	Therapeutics
2.	Duration of Therapy
3.	Percutaneous Nephrolithotomy
4.	Antibiotic Prophylaxis
5.	Stents