Muscular Diseases (Myopathy)

01/01/2021 - "To date, no randomized controlled trials have been conducted to identify the most effective treatment for statin-associated autoimmune myopathy. "
12/01/2022 - "Statins are associated with side effects, most commonly myopathy and myalgias, despite their proven efficacy. "
12/01/2006 - "Although statins are prescribed as relatively safe and effective drugs for hypercholesterolemic patients, it has been reported that a significant side effect, myopathy, occurs infrequently during medication. "
01/01/2021 - "More studies and reports are needed to confirm the utility and efficacy of SCIG in statin-associated necrotising autoimmune myopathy, as well as to provide information about dosing, tolerability, and durability of SCIG in the treatment of statin-associated necrotising autoimmune myopathy."
01/01/2013 - "Reducing statin-related muscle disorder would likely improve overall patient compliance, thereby leading to an increase in improved short- and long-term outcomes associated with appropriate use of statins."

02/01/1985 - "High-dose corticosteroids were dramatically effective in inducing remission, with resolution of all signs and symptoms of the myopathy and normalization of CPK."
08/01/2000 - "These improved initially with more frequent infusions of hdIVIg but oral corticosteroids were required to treat worsening myopathy. "
08/01/1976 - "The myopathy and malabsorption improved with corticosteroid treatment. "
01/01/2019 - "Quantitative electromyography is an important tool to evaluate myopathies, and some difficult-to-treat asthmatic patients may have a subclinical corticosteroid myopathic process, using only inhaled corticosteroid, according to some studies. "
01/01/2019 - "The findings of this study may provide a tool to evaluate corticosteroid myopathy."

11/01/2018 - "Second, we show that muscle echo intensity can be useful to track the progression of steroid myopathy overtime and may help to indicate early response to therapeutic interventions. "
05/04/2022 - "The primary purpose of this study is to establish whether an individualized circuit-based program will reduce steroid-induced muscle myopathy, as indicated by maintained or improved functional fitness for patients on active treatment and receiving steroids. "
01/01/2019 - "His myopathy improved after 2 weeks of steroid treatment. "
12/01/1999 - "The influence of mild exercise on skeletal muscle fibers was investigated histochemically to assess the effects of exercise on steroid myopathy and its efficacy for preventing this disease. "
04/01/2024 - "In this study, we engineered a functional three-dimensional (3D) in vitro skeletal muscle model to investigate steroid myopathy. "

03/01/2024 - "We raise the need for further studies regarding the role of thin filament proteins in the central nervous system and for a systematic cognitive assessment of congenital myopathy patients."
02/01/2024 - "The results of this study point out that the medaka fish larva is a suitable model for the investigation of the genotype/phenotype correlations and therapeutic possibilities in skeletal muscle diseases caused by mutations in sarcomeric proteins.NEW & NOTEWORTHY The suitability of the medaka fish as a model for investigating the molecular mechanisms of human myopathies caused by mutations of sarcomeric proteins is tested by combining structural analysis and sarcomere-level mechanics of the skeletal muscle of the tail of medaka larva. "
01/01/2024 - "Considering the high prevalence of these myopathies in FG broilers and that a worsening is observed as the bird slaughter age is increased, the present study was intended to evaluate the distribution and the expression level of COL4 protein and its coding genes in PMs of FG broilers at different stages of muscle development (i.e., 7, 14, 21, 28, 35, and 42 d of age). "
01/01/2023 - "This study also reveals the stoichiometry of major proteins involved in excitation contraction coupling and identifies novel potential pharmacological targets to treat RyR1-related congenital myopathies."
01/01/2023 - "To gain a comprehensive understanding of the molecular pathogenesis of this acquired myopathy and to define proteins targets as well as pathophysiological processes beyond impaired proteolysis, utilising CQ-treated C2C12 cells and muscle biopsies derived from CQ-myopathy patients, we performed different proteomic approaches and Coherent Anti-Stokes Raman Scattering (CARS) microscopy, in addition to immunohistochemical studies. "

01/01/2016 - "Defects of coenzyme Q10 (CoQ10) metabolism cause a variety of disorders ranging from isolated myopathy to multisystem involvement. "
12/01/2014 - "Coenzyme Q10 (CoQ10) deficiency can manifest diversely, from isolated myopathy to multisystem involvement. "
01/01/2010 - "The purpose of this multicenter study was to evaluate the frequency of muscle CoQ(10) deficiency in a cohort of 76 patients presenting with clinically heterogeneous mitochondrial phenotypes which included myopathy among their clinical features. "
06/01/2004 - "Clinical laboratory monitoring of coenzyme Q10 use in neurologic and muscular diseases."
11/01/1992 - "Coenzyme Q10 administration appeared to be ineffective in preventing this experimental myopathy."

01/01/2022 - "Role of Intravenous Immunoglobulin in Necrotizing Autoimmune Myopathy."
02/26/2021 - "Seronegative necrotizing autoimmune myopathy with favorable response to intravenous immunoglobulin."
01/01/2019 - "IVIG-treated patients with myopathy displayed enhanced expression of CD69 on basophils. "
01/01/2019 - "Basophil phenotypes were also analyzed from IVIG-treated patients with myopathy. "
03/01/2018 - "A case of refractory acute sarcoid myopathy successfully treated with intravenous immunoglobulin."

01/01/2020 - "The response to rituximab and subsequent sustained remission suggests a role for early use of rituximab in aggressive cases of anti-HMGCR myopathy."
01/01/2019 - "Our objective was to assess efficacy of rituximab (RTX) in anti-HMGCR immune-mediated necrotizing myopathy. "
07/01/2021 - "Given the histological and clinical severity of the myopathy, mycophenolate (500 mg twice a day) and rituximab (360 mg/m2, 4 weekly infusions) were added. "
05/01/2021 - "Rituximab use for refractory anti-HMGCR immune-mediated necrotizing myopathy: A case report."
01/01/2021 - "Rituximab in the treatment of immune-mediated necrotizing myopathy: a review of case reports and case series."

08/01/1988 - "Furthermore, the enzyme activity significantly increased, with resolution or improvement in the myopathy, in patients who abstained from alcohol. "
01/08/2021 - "TIS consists of composite response criteria, combining weighted improvement in 6 core set measures (CSMs), Global Disease Activity (Physician and Patient), manual muscle testing-8 (MMT-8), Health Assessment Questionnaire, extra-muscular disease activity, and muscle enzymes. "
09/01/2022 - "Improved understanding of horse management effects on serum muscle enzyme activity as markers of muscle health would assist interpretation of serum muscle enzyme activity and guide management to reduce myopathy risk. "
04/01/2024 - "In this study, differences in various enzyme activities and increased DNA damage suggest that RRM2-mediated mitochondrial abnormalities may play a role in WB myopathy."
09/01/2022 - "We advise caution in relying solely on serum muscle enzyme activity for diagnosis of myopathy until the strength of association between CK and myopathy is further ascertained in future studies."

05/01/2014 - "This is the first report of a pediatric patient indicating that the serum levels of anti-SRP54 antibodies are also beneficial for monitoring the disease activity of progressive necrotizing myopathy."
01/01/2018 - "Furthermore, patients with anti-NXP2 antibodies, mostly assigned in the first cluster, also displayed more severe muscular disease, requiring more aggressive treatment and having a lower remission rate during the follow-up period. "
01/01/2020 - "A noteworthy spontaneous improvement in her weakness suggested the possibility of an acquired autoimmune myopathy, confirmed by positive testing of anti-HMGCR antibodies titers. "
04/01/2024 - "Immune-mediated necrotizing myopathy: antibodies and forecast. "
02/07/2024 - "Immune-Mediated Necrotizing Myopathy (IMNM): A Story of Antibodies."

09/25/2018 - "In one patient, initiation of oral prednisolone seemed to correlate with a steady improvement in her proximal myopathy. "
02/18/2024 - "However, long-term administration of prednisolone can promote myopathy. "
07/01/2021 - "Resolution of necrotising myopathy was observed after a short course of anti-inflammatory prednisolone and nutritional supplementation. "
01/01/2017 - "She was diagnosed with immune-mediated necrotizing myopathy (IMNM) and treated with prednisolone. "
08/01/1993 - "Finally, 90 min daily of endurance exercise did not antagonize prednisolone-induced myopathy in either the diaphragm or the plantaris."

01/01/2022 - "The promise of stem cell therapy is not new and has been used successfully to treat non-arthritic diseases, such as hematopoietic and muscle disorders. "
03/01/1993 - "We feel that the development of this technique may make autogenous myoblast transfer therapy a useful treatment for congenital ptosis and other focal myopathies."
01/01/2018 - "A wide range of potential congenital myopathy therapies have been investigated on the basis of improved understanding of disease pathomechanisms, and some therapies are in clinical trials. "
11/01/2019 - "Improved understanding of molecular mechanisms in inherited myopathies is enabling the development of experimental molecular therapies with clinical potential. "
01/01/2024 - "Both animal and in vitro cell-based model systems are generated to elucidate the mechanism of GNE myopathy and evaluate the efficacy of therapies. "

06/01/2021 - "This population pharmacokinetic model can be used to evaluate ManNAc dosing regimens and to calculate Neu5Ac production and exposure following oral administration of ManNAc in subjects with GNE myopathy."
06/01/2021 - "A semi-mechanistic population pharmacokinetic model was developed to simultaneously characterize plasma ManNAc and its metabolite Neu5Ac following oral administration of ManNAc to subjects with GNE myopathy. "
10/23/2015 - "Myopathy in knockout mice was completely rescued by the oral administration of MVA. "
01/01/2009 - "She was given a diagnosis of sarcoid myopathy, and motor weakness and abnormal intensity signals on T2WI in this patient were dramatically improved with oral administration of prednisolone (40 mg/day)."
01/01/2023 - "The present study indicates that oral administration of SA-ER tablets is effective and safe in patients with GNE myopathy in Japan."

03/01/2020 - "We hypothesize that this case represents an atypical presentation of AML with an immune-mediated necrotizing-like myopathy as a possible paraneoplastic manifestation of the disease, which improved after initiating chemotherapy. "
05/01/2023 - "Drug therapy should be added on the basis of appropriate evaluation and fundamental symptomatic treatment including rehabilitation, in genetic myopathy."
10/01/2021 - "At present, there are no approved drug therapies for any subtype of congenital myopathy.In"
01/01/2017 - "Multimodal Drug Therapy and Physical Rehabilitation in the Successful Treatment of Capture Myopathy in a Lesser Flamingo (Phoeniconaias minor)."
10/01/2016 - "Here, we review the current literature describing the clinical manifestations and molecular origins of chemotherapy-induced myopathy with a focus on the mitochondria as the target organelle via which chemotherapeutic agents establish toxicity. "

01/01/2019 - "Diagnosis of patients with a LGMD-like presentation of anti-HMGCR myopathy is critical because these patients may respond favorably to immunotherapy, especially those with shorter disease duration."
01/01/2021 - "Myalgias upon PD-1 checkpoint blockade: Think of immunotherapy induced hypothyroid myopathy."
01/01/2020 - "Her myopathy symptoms had been initially attributed to GVHD, but when she progressed despite immunotherapy, genetic testing was requested. "
01/01/2020 - "Immune-mediated necrotizing myopathy (IMNM) is a rare form of idiopathic immune myopathy (IIM) that requires immunotherapies, including immunosuppressive medications, if severe. "
01/01/2018 - "Necrotizing myopathy patients may require more aggressive immunotherapy due to their grave prognosis."

07/01/2009 - "Hypothyroid dogs developed electromyographic and morphologic evidence of myopathy by 6 months after treatment, which persisted throughout the study, although these changes were subclinical at all times. "
11/01/1966 - "[Hypothyroid myopathies: optic and electron microscopic study before and after treatment]."
07/01/2014 - "Myopathy was assessed before and after treatment. "
09/01/2012 - "Exercise genes may provide a new opportunity for studying the outcome after treatment and the muscle regeneration abilities in other models of genetic myopathies."
08/01/1998 - "P100 latency of the PR-VEPs in MG patients before and after treatment was delayed compared to normal controls, while there were no differences between ocular myopathy patients and normal controls. "