Dexamethasone (Maxidex)

An anti-inflammatory 9-fluoro-glucocorticoid.

Also Known As:

Maxidex; Decaspray; Decaject; Decaject-L.A.; Decameth; Dexasone; Dexpak; Hexadrol; Methylfluorprednisolone; Millicorten; Oradexon; Decaject L.A.; Hexadecadrol; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-

Networked: 23674 relevant articles (2955 outcomes, 4630 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 7
- Fused-Ring Compounds
  - Steroids: 71426
    - Fluorinated Steroids: 33
      - Dexamethasone: 23674
        dexamethasone 21-phosphate: 227
        Desoximetasone: 55
        dexamethasone acetate: 44
        VAD regimen: 30
        Dexa-BEAM protocol: 25
        Dexamethasone Drug Combination Tobramycin: 15
        Dexamethasone Isonicotinate: 13
        dexamethasone 21-methanesulfonate: 10
        corticosteroid methanetriol mixture: 8
        PD protocol: 8
        polymyxin B drug combination neomycin dexamethasone: 8
        vitamin B12 drug combination thiamine phenylbutazone dexamethasone aminopyrine: 8
        FND protocol: 7
        CVAD protocol: 6
        Otomize: 5
        VAD protocol: 5
        Sofradex: 4
        auricularum: 3
        dexamethasone 17-valerate: 3
        DHAP protocol: 3
        dexamethasone 21-palmitate: 2
        dexamethasone glucuronide: 2
        exosterol: 2
        M-BACOD protocol: 2
        MDT protocol: 2
        modified ESHAP regimen: 2
        percutalgine: 2
        tyzanol drug combination pyridine carboxylate of dexamethasone neomycin sulfate: 2
        21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione: 1
        ALL-VI protocol: 1
        Berlin-Frankfurt-Muenster protocol II: 1
        CEVAD protocol: 1
        CHASE protocol: 1
        CMED protocol: 1
        DAI protocol: 1
        DCEP protocol: 1
        Dexa-PAMB protocol: 1
        dexamethasone drug combination cysteamine ascorbic acid: 1
        dexamethasone linoleate: 1
        dexamethasone oxetanone: 1
        dexamethasone succinate dextran: 1
        dexamethasone sulfate ester: 1
        dexamethasone trimethyl acetate: 1
        DFCI 91-01 protocol: 1
        DFCI 95-01 protocol: 1
        DHACT protocol: 1
        Doxiproct Plus: 1
        FLUDAP protocol: 1
        G-IDEA protocol: 1
        ND8008: 1
        neomycin drug combination dexamethasone chloramphenicol: 1
        orphenadrine drug combination metoclopramide dexamethasone chlorpromazine: 1
        supertendin: 1
        thymol drug combination parachlorophenol dimethyllauryl benzylammonium dexamethasone: 1
        Tresaderm: 1
        TVTG protocol: 1
        VCD protocol: 1
        VMD protocol: 1
        11-dehydrodexamethasone
        11-ketodexamethasone
        21-((aminopropyl)thio)dexamethasone
        21-((mercaptobutyl)thio)dexamethasone
        4-(carboxymethylthio)dexamethasone
        6-hydroxydexamethasone
        6-hydroxydexamethasone 17-propionate
        ALL-85 protocol
        BACOD protocol
        BACOD-VP16 protocol
        BBVDD protocol
        BFM-ALL 81 protocol
        BMPD protocol
        CAD protocol 3
        CBVD protocol
        CEOP-IMVP-Dexa regimen
        CEVD protocol
        CIOD protocol
        Cis-VACD protocol
        CMD protocol
        CODBLAM IV protocol
        CVAD-V protocol
        DCTER protocol
        DEMOB protocol
        dexamethasone 17-propionate
        dexamethasone 21-(beta-isothiocyanatoethyl)thioether
        dexamethasone 21-bromoacetate
        dexamethasone 21-glucoside
        dexamethasone 21-iodoacetate
        dexamethasone 21-phenylpropionate
        dexamethasone 21-tributylacetate
        dexamethasone dipropionate
        dexamethasone drug combination clemastine
        dexamethasone drug combination clotrimazole azidoamphenicol
        dexamethasone trioxa undecanoate
        dexamethasone-(C21-phosphoramide)-(anti-EGFR)
        dexamethasone-17-carboxamide
        dexamethasone-21-sulfobenzoate
        dexamethasone-beta-cyclodextrin
        dexamethasone-bis-peptide nucleic acid
        dexamethasone-FK506 heterodimer
        DHAOx protocol
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienetriols
        Dexamethasone: 23674
        dexamethasone 21-phosphate: 227
        dexamethasone acetate: 44
        VAD regimen: 30
        Dexa-BEAM protocol: 25
        Dexamethasone Drug Combination Tobramycin: 15
        Dexamethasone Isonicotinate: 13
        dexamethasone 21-methanesulfonate: 10
        corticosteroid methanetriol mixture: 8
        PD protocol: 8
        polymyxin B drug combination neomycin dexamethasone: 8
        vitamin B12 drug combination thiamine phenylbutazone dexamethasone aminopyrine: 8
        FND protocol: 7
        CVAD protocol: 6
        Otomize: 5
        VAD protocol: 5
        Sofradex: 4
        auricularum: 3
        dexamethasone 17-valerate: 3
        DHAP protocol: 3
        dexamethasone 21-palmitate: 2
        dexamethasone glucuronide: 2
        exosterol: 2
        M-BACOD protocol: 2
        MDT protocol: 2
        modified ESHAP regimen: 2
        percutalgine: 2
        tyzanol drug combination pyridine carboxylate of dexamethasone neomycin sulfate: 2
        21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione: 1
        ALL-VI protocol: 1
        Berlin-Frankfurt-Muenster protocol II: 1
        CEVAD protocol: 1
        CHASE protocol: 1
        CMED protocol: 1
        DAI protocol: 1
        DCEP protocol: 1
        Dexa-PAMB protocol: 1
        dexamethasone drug combination cysteamine ascorbic acid: 1
        dexamethasone linoleate: 1
        dexamethasone oxetanone: 1
        dexamethasone succinate dextran: 1
        dexamethasone sulfate ester: 1
        dexamethasone trimethyl acetate: 1
        DFCI 91-01 protocol: 1
        DFCI 95-01 protocol: 1
        DHACT protocol: 1
        Doxiproct Plus: 1
        FLUDAP protocol: 1
        G-IDEA protocol: 1
        ND8008: 1
        neomycin drug combination dexamethasone chloramphenicol: 1
        orphenadrine drug combination metoclopramide dexamethasone chlorpromazine: 1
        supertendin: 1
        thymol drug combination parachlorophenol dimethyllauryl benzylammonium dexamethasone: 1
        Tresaderm: 1
        TVTG protocol: 1
        VCD protocol: 1
        VMD protocol: 1
        11-dehydrodexamethasone
        11-ketodexamethasone
        21-((aminopropyl)thio)dexamethasone
        21-((mercaptobutyl)thio)dexamethasone
        4-(carboxymethylthio)dexamethasone
        6-hydroxydexamethasone
        6-hydroxydexamethasone 17-propionate
        ALL-85 protocol
        BACOD protocol
        BACOD-VP16 protocol
        BBVDD protocol
        BFM-ALL 81 protocol
        BMPD protocol
        CAD protocol 3
        CBVD protocol
        CEOP-IMVP-Dexa regimen
        CEVD protocol
        CIOD protocol
        Cis-VACD protocol
        CMD protocol
        CODBLAM IV protocol
        CVAD-V protocol
        DCTER protocol
        DEMOB protocol
        dexamethasone 17-propionate
        dexamethasone 21-(beta-isothiocyanatoethyl)thioether
        dexamethasone 21-bromoacetate
        dexamethasone 21-glucoside
        dexamethasone 21-iodoacetate
        dexamethasone 21-phenylpropionate
        dexamethasone 21-tributylacetate
        dexamethasone dipropionate
        dexamethasone drug combination clemastine
        dexamethasone drug combination clotrimazole azidoamphenicol
        dexamethasone trioxa undecanoate
        dexamethasone-(C21-phosphoramide)-(anti-EGFR)
        dexamethasone-17-carboxamide
        dexamethasone-21-sulfobenzoate
        dexamethasone-beta-cyclodextrin
        dexamethasone-bis-peptide nucleic acid
        dexamethasone-FK506 heterodimer
        DHAOx protocol
        DICE protocol

Experts

1.	Moreau, Philippe: 151 articles (05/2024 - 11/2006)
2.	Richardson, Paul G: 137 articles (05/2024 - 06/2002)
3.	Dimopoulos, Meletios A: 121 articles (02/2024 - 01/2002)
4.	Facon, Thierry: 85 articles (03/2024 - 06/2005)
5.	Leleu, Xavier: 78 articles (05/2024 - 11/2006)
6.	Sonneveld, Pieter: 75 articles (02/2024 - 03/2003)
7.	Cavo, Michele: 74 articles (05/2024 - 09/2002)
8.	Anderson, Kenneth C: 71 articles (02/2024 - 02/2002)
9.	Oriol, Albert: 66 articles (03/2024 - 10/2007)
10.	Lonial, Sagar: 58 articles (11/2023 - 06/2005)

Related Diseases

1.	Multiple Myeloma 01/01/1998 - "The authors describe a case of multiple myeloma in which a complete remission was obtained by treatment with high dose dexamethasone. " 10/01/2009 - "The high-dose dexamethasone-based regiments are safe and effective for newly diagnosed multiple myeloma patients with renal impairment." 02/01/1999 - "The use of biological modifiers in combination with dexamethasone offer a safe and effective therapeutic option in patients with refractory multiple myeloma. " 01/01/2023 - "A phase I first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone in patients with progressive multiple myeloma." 01/01/2022 - "This study is aimed at exploring whether the presence of MSCs affects dexamethasone's antitumor effects against multiple myeloma. "
2.	Vomiting 04/01/2008 - "A significant reduction in vomiting from 27% to 11% was achieved following the introduction of routine use of intravenous dexamethasone during surgery. " 04/01/2003 - "Compared with placebo, dexamethasone significantly decreased the incidence of early and late vomiting (P < 0.05, P < 0.001 respectively). " 02/01/1995 - "Addition of dexamethasone significantly improved prevention of both acute and delayed emesis. " 01/01/1998 - "Six patients in group D and 19 in group S experienced vomiting at least once within the 24-h postoperative period; dexamethasone was effective in reducing the overall incidence of vomiting from 63.3% to 20.0% (P < 0.01). " 10/01/2000 - "Dexamethasone is clearly effective in protecting from emesis both in the acute and delayed phases, with emesis avoided in one patient out of six treated. "
3.	Postoperative Nausea and Vomiting (PONV) 02/01/2001 - "Of them, dexamethasone used as a prophylactic drug for PONV provided the best results. " 01/01/2008 - "Dexamethasone has been proven effective in the prophylaxis of late PONV. " 05/04/2024 - "Dexamethasone (DXM), commonly administered to prevent postoperative nausea and vomiting (PONV), has potential anti-inflammatory effects that might be beneficial in reducing these complications. " 02/29/2024 - "Additionally, administering dexamethasone at a dosage of 8-10 mg was found to be significantly more effective in reducing the incidence of PONV than was a dosage of 4-5 mg (OR 0.39; 95% CI: 0.19-0.80; I2=29%; P=0.01). " 12/01/2023 - "However, the use of dexamethasone as an adjuvant is a good alternative option, particularly due to its lower cost and reduced incidence of adverse effects such as postoperative nausea and vomiting."
4.	Nausea 01/01/2016 - "In these patients, NEPA plus dexamethasone, as compared to standard treatments, achieved superior efficacy in all primary and secondary end points during the acute, delayed, and overall phases, including nausea assessment. " 01/01/2016 - "Dexamethasone 4mg was not effective preventing nausea in our study. " 09/01/2022 - "There was also an improvement on the incidence of nausea on the dexamethasone group compared to control." 09/01/2022 - "The incidence of PDPH (8.3% vs 25.0%; p = .002) and nausea (11.5% vs 25.0%; p = .015) were significantly lower in dexamethasone group. " 07/01/2022 - "Multivariate logistic analysis suggested that patients with no-to-low alcohol consumption and those administered 6.6 mg dexamethasone on day 1 were at a higher risk of acute nausea. "
5.	Macular Edema 01/01/2024 - "Results at 6-month follow-up showed that intravitreal dexamethasone (DEX) was the most effective in improving patients' bestcorrected visual acuity and reducing the thickness of central macular edema. " 01/01/2021 - "To determine the impact of different baseline clinical characteristics on the improvement in best corrected visual acuity (BCVA) in patients with diabetic macular edema (DME) who underwent the intravitreal dexamethasone implant (DEX) Ozurdex®. " 01/01/2017 - "To assess the effect on best-corrected visual acuity (BCVA) and efficacy of the intravitreal sustained-release 0.7 mg dexamethasone implant (Ozurdex; Allergan, Irvine, CA) in patients with recalcitrant diabetic macular edema (DME). " 01/01/2016 - "The dexamethasone implant improved macular edema in refractory cases resulting in statistically significant improvements in best-corrected visual acuity and central macular thickness that remained stable to 3 months and 6 months, respectively." 12/01/2022 - "intravitreal dexamethasone implant is effective in the treatment of diabetic center-involving macular edema and was associated with significant improvements in BCVA and CMT at 2 months after injection. "

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Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Injections
4.	Stem Cell Transplantation
5.	Aftercare (After-Treatment)