Cephalexin (Cefalexin)

A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.

Also Known As:

Cefalexin; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-; Cephalexin Dihydride; Cephalexin Hemihydrate; Cephalexin Hydrochloride; Cephalexin Monohydrate; Cephalexin Monohydrochloride; Cephalexin Monohydrochloride, Monohydrate; Cephalexin, (6R-(6alpha,7alpha(R*)))-Isomer; Cephalexin, (6R-(6alpha,7beta(S*)))-Isomer; Cephalexin, (6R-(6alpha,7beta))-Isomer; Cephalexin, Monosodium Salt; Cephalexin, Monosodium Salt, (6R-(6alpha,7beta))-Isomer; Ceporexine; Palitrex

Networked: 706 relevant articles (83 outcomes, 105 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Autmizguine, Julie: 3 articles (07/2022 - 12/2013)
2.	Butler, Christopher C: 3 articles (03/2019 - 09/2014)
3.	Heal, Clare F: 3 articles (01/2019 - 07/2014)
4.	Miller, Loren G: 3 articles (12/2017 - 06/2012)
5.	Goby, L: 3 articles (06/2012 - 12/2009)
6.	Pichichero, Michael E: 3 articles (03/2007 - 02/2006)
7.	Haynes, Andrew S: 2 articles (04/2024 - 01/2022)
8.	Parker, Sarah K: 2 articles (04/2024 - 01/2022)
9.	Peñuela, Gustavo A: 2 articles (11/2021 - 06/2020)
10.	Zúñiga-Benítez, Henry: 2 articles (11/2021 - 06/2020)

Related Diseases

1.	Infections 08/01/1991 - "However, by recommending a 1-day strategy of oral cephalexin only to those dental patients at high risk for late prosthetic joint infections rather than a 3-day regimen to all patients, the cost effectiveness improved from $1.1 million/QALY to $446,100/QALY while maintaining a low risk of death (0.38 deaths per 10(6) dental visits)." 03/01/1982 - "Cephalexin appeared to be equally effective in treatment of both ACB-positive and ACB-negative infections. " 01/01/2005 - "Fixation problems included two pin-track infections cleared with oral cephalexin and one broken half-pin. " 03/01/1986 - "Those patients with infections caused by cephalexin-susceptible organisms were cured at a rate similar to that for patients with infections caused by cephalexin-resistant organisms (68 versus 50%; P = 0.62). " 04/01/1981 - "The efficacy of cephalexin administered twice a day was compared to the same drug administered four times a day for the treatment of skin and skin structure infections due to staphylococcus and/or streptococcus. "
2.	Urinary Tract Infections (Urinary Tract Infection) 11/01/1989 - "Postcoital oral cephalexin prophylaxis is highly effective in the prevention of recurrent urinary tract infection in the nonpregnant as well as pregnant premenopausal women because of easy compliance, the high urine concentration achieved and the minimal induction of resistance to cephalexin in the introital gram-negative bacterial flora. " 01/01/1983 - "Cephalexin is essentially nontoxic at recommended doses, and its clinical efficacy in urinary tract infections has been repeatedly documented in numerous studies since 1971." 03/20/1973 - "[Clinical and bacteriological studies on the course of 31 cases of most severe chronic urinary tract infections during mainly discordant cephalexin medication]." 09/01/2023 - "Two Times Versus Four Times Daily Cephalexin Dosing for the Treatment of Uncomplicated Urinary Tract Infections in Females." 08/25/2021 - "To evaluate the ability of bacterial scatter diagrams generated from the automated urine particle analyzer (UF-1000i, Sysmex, Kobe, Japan) to pre-estimate the treatment efficacy of oral cefalexin in treating women with uncomplicated urinary tract infection (uUTI). "
3.	Wounds and Injuries (Trauma) 01/01/2021 - "One patient had delayed wound healing treated prophylactically with cephalexin; although the wound healed, the patient developed a boutonniere deformity requiring surgery. " 01/01/2019 - "We hypothesized that: (1) cephalexin provides adequate antibiotic coverage for acute Seymour fractures; (2) most injuries will achieve good outcomes with management in the emergency department (ED) alone; and (3) indication for operative intervention is unsuccessful or unstable reduction in the ED. " 12/01/1998 - "Mupirocin cream applied topically 3 times daily is as effective as oral cephalexin given 4 times daily for the treatment of secondarily infected wounds and was well tolerated." 12/01/1998 - "Mupirocin cream is as effective as oral cephalexin in the treatment of secondarily infected wounds." 11/01/1988 - "Efficacy of perioperative cefamandole with postoperative cephalexin in the primary outpatient treatment of open wounds of the hand."
4.	Cellulitis 07/01/2022 - "With a success rate of 89.7%, HD oral cephalexin seems effective and safe for the treatment of children with moderate cellulitis. " 01/01/2023 - "This pilot randomized controlled trial comparing high-dose to standard-dose cephalexin for ED patients with cellulitis demonstrated a high participant recruitment rate and that a full-scale trial is feasible. " 01/01/2023 - "To evaluate the feasibility of a randomized trial comparing high-dose (1000 mg) to standard-dose (500 mg) cephalexin to treat ED patients with cellulitis. " 08/01/2016 - "The primary objective of this study was to compare therapeutic failure rates in non-obese and morbidly obese patients with cellulitis when treated with cephalexin at standard dosing. " 06/01/2000 - "Eleven (2.8%) of 393 study patients had been initially treated with cephalexin prior to our evaluation; 9 (82%) were originally diagnosed with cellulitis. "
5.	Pyoderma 08/01/2008 - "Once-daily cephalexin is as effective as twice-daily cephalexin in the treatment of canine superficial pyoderma." 12/01/2010 - "The second study was an open trial of 2CA monotherapy in eight dogs with cefalexin-resistant Staphylococcus intermedius group-associated superficial pyoderma. " 08/01/2008 - "The aims of this study were to evaluate the efficacy and tolerability of oral cephalexin given at 30 mg/kg once daily in dogs with superficial pyoderma and to compare them with those of oral cephalexin given at 15 mg/kg twice daily. " 08/01/2008 - "Efficacy and tolerability of once-daily cephalexin in canine superficial pyoderma: an open controlled study." 08/01/2008 - "Twenty dogs with superficial pyoderma were treated with cephalexin at 30 to 60 mg/kg orally once daily (group A) and compared with 20 dogs treated at a dose of 15 to 30 mg/kg orally twice daily (group B). "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Ampicillin (Omnipen)
3.	Cefadroxil (Duricef)
4.	Cephalosporins (Cephalosporin Antibiotics)
5.	Cefazolin (Ancef)
6.	Clindamycin (Cleocin)
7.	retapamulin
8.	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)
9.	Amoxicillin (Wymox)
10.	Trimethoprim (Proloprim)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Duration of Therapy
4.	Oral Administration
5.	Antibiotic Prophylaxis